The interaction of arsenoplatin-1 (AP-1), a promising dual-action anticancer metallodrug featuring the simultaneous presence of a cisplatin-like center and an arsenite center, with proteins was studied via a synergetic experimental and theoretical approach. The reactivity of AP-1 with a variety of proteins was analyzed through ESI MS measurements and, at the same time, the reactions of AP-1 with molecular models of the side chains of histidine, methionine, cysteine, and selenocysteine were analyzed through a computational approach
Reactions of Arsenoplatin-1 with Protein Targets: A Combined Experimental and Theoretical Study (2022) Inorganic Chemistry / Tolbatov, I., Cirri, D., Tarchi, M., Marzo, T., Coletti, C., Marrone, A., Messori, L., Re, N., Massai, L.. - In: INORGANIC CHEMISTRY. - ISSN 1520-510X. - ELETTRONICO. - (2022), pp. 3240-3248. [10.1021/acs.inorgchem.1c03732]
Reactions of Arsenoplatin-1 with Protein Targets: A Combined Experimental and Theoretical Study (2022) Inorganic Chemistry
Cirri D.;Marzo T.;Marrone A.;Messori L.;Massai L.
2022
Abstract
The interaction of arsenoplatin-1 (AP-1), a promising dual-action anticancer metallodrug featuring the simultaneous presence of a cisplatin-like center and an arsenite center, with proteins was studied via a synergetic experimental and theoretical approach. The reactivity of AP-1 with a variety of proteins was analyzed through ESI MS measurements and, at the same time, the reactions of AP-1 with molecular models of the side chains of histidine, methionine, cysteine, and selenocysteine were analyzed through a computational approach
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