Mapping the genetic landscape across 14 psychiatric disorders

Grotzinger, Ad; Werme, J; Peyrot, Wj; Frei, O; De Leeuw, C; Bicks, Lk; Guo, Q; Margolis, Mp; Coombes, Bj; Batzler, A; Pazdernik, V; Biernacka, Jm; Andreassen, Oa; Anttila, V; Børglum, Ad; Breen, G; Cai, N; Demontis, D; Edenberg, Hj; Faraone, Sv; Franke, B; Gandal, Mj; Gelernter, J; Hatoum, As; Hettema, Jm; Johnson, Ec; Jonas, Kg; Knowles, Ja; Koenen, Kc; Maihofer, Ax; Mallard, Tt; Mattheisen, M; Mitchell, Ks; Neale, Bm; Nievergelt, Cm; Nurnberger, Ji; O'Connell, Ks; Peterson, Re; Robinson, Eb; Sanchez-Roige, Ss; Santangelo, Sl; Scharf, Jm; Stefansson, H; Stefansson, K; Stein, Mb; Strom, Ni; Thornton, Lm; Tucker-Drob, Em; Verhulst, B; Waldman, Id; Walters, Gb; Wray, Nr; D, Yu; Anxiety Disorders Working Group Of The Psychiatric Genomics Consortium,; Attention-Deficit/Hyperactivity Disorder (ADHD) Working Group of the Psychiatric Genomics Consortium,; Autism Spectrum Disorders Working Group Of The Psychiatric Genomics Consortium,; Bipolar Disorder Working Group Of The Psychiatric Genomics Consortium,; Eating Disorders Working Group Of The Psychiatric Genomics Consortium,; Ricca, V; Major Depressive Disorder Working Group Of The Psychiatric Genomics Consortium,; Nicotine Dependence GenOmics (iNDiGO) Consortium,; Obsessive-Compulsive Disorder and Tourette syndrome,

triangulating across a suite of cutting-edge statistical and functional genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders (1,056,201 cases). Using genetic association data from common variants, we identified and characterized five underlying genomic factors that explained the majority of the genetic variance of the individual disorders (around 66% on average) and were associated with 238 pleiotropic loci

Mapping the genetic landscape across 14 psychiatric disorders / Grotzinger AD, Werme J, Peyrot WJ, Frei O, de Leeuw C, Bicks LK, Guo Q, Margolis MP, Coombes BJ, Batzler A, Pazdernik V, Biernacka JM, Andreassen OA, Anttila V, Børglum AD, Breen G, Cai N, Demontis D, Edenberg HJ, Faraone SV, Franke B, Gandal MJ, Gelernter J, Hatoum AS, Hettema JM, Johnson EC, Jonas KG, Knowles JA, Koenen KC, Maihofer AX, Mallard TT, Mattheisen M, Mitchell KS, Neale BM, Nievergelt CM, Nurnberger JI, O'Connell KS, Peterson RE, Robinson EB, Sanchez-Roige SS, Santangelo SL, Scharf JM, Stefansson H, Stefansson K, Stein MB, Strom NI, Thornton LM, Tucker-Drob EM, Verhulst B, Waldman ID, Walters GB, Wray NR, Yu D; Anxiety Disorders Working Group of the Psychiatric Genomics Consortium; Attention-Deficit/Hyperactivity Disorder (ADHD) Working Group of the Psychiatric Genomics Consortium; Autism Spectrum Disorders Working Group of the Psychiatric Genomics Consortium; Bipolar Disorder Working Group of the Psychiatric Genomics Consortium; Eating Disorders Working Group of the Psychiatric Genomics Consortium; Ricca V; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium; Nicotine Dependence GenOmics (iNDiGO) Consortium; Obsessive-Compulsive Disorder and Tourette syndrome. - In: NATURE. - ISSN 0028-0836. - ELETTRONICO. - (In corso di stampa), pp. 0-0.