We report the case of a stage 4 mantle cell lymphoma patient, resistant to conventional first- and second-line therapies, treated with CAR-T cells. The therapy was initially efficacious, with an appreciable CAR-T cells expansion in vivo. However, downregulation of CD19 expression on malignant B cells led to sudden therapy failure.
Downregulation of CD19 Expression Associates With Mantle Cell Lymphoma Relapse Following CAR-T Cell Therapy / Peruzzi, B., Mazzoni, A., Cutini, I., Matani, F., Caporale, R., Bencini, S., Pratesi, S., Maggi, L., Capone, M., Vanni, A., Lamacchia, G., Bartoli, L., Liotta, F., Cosmi, L., Puccini, B., Nassi, L., Sordi, B., Camerini, C., Vannucchi, A.M., Nozzoli, C., et al.. - In: EUROPEAN JOURNAL OF IMMUNOLOGY. - ISSN 1521-4141. - ELETTRONICO. - 56:(2026), pp. e70123.0-e70123.0. [10.1002/eji.70123]
Downregulation of CD19 Expression Associates With Mantle Cell Lymphoma Relapse Following CAR-T Cell Therapy
Mazzoni, Alessio;Matani, Francesca;Maggi, Laura;Capone, Manuela;Vanni, Anna;Lamacchia, Giulia;Bartoli, Lucia;Liotta, Francesco;Cosmi, Lorenzo;Vannucchi, Alessandro Maria;Annunziato, Francesco
2026
Abstract
We report the case of a stage 4 mantle cell lymphoma patient, resistant to conventional first- and second-line therapies, treated with CAR-T cells. The therapy was initially efficacious, with an appreciable CAR-T cells expansion in vivo. However, downregulation of CD19 expression on malignant B cells led to sudden therapy failure.
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