We report the case of a stage 4 mantle cell lymphoma patient, resistant to conventional first- and second-line therapies, treated with CAR-T cells. The therapy was initially efficacious, with an appreciable CAR-T cells expansion in vivo. However, downregulation of CD19 expression on malignant B cells led to sudden therapy failure.
Downregulation of CD19 Expression Associates With Mantle Cell Lymphoma Relapse Following CAR-T Cell Therapy / Peruzzi, Benedetta; Mazzoni, Alessio; Cutini, Ilaria; Matani, Francesca; Caporale, Roberto; Bencini, Sara; Pratesi, Sara; Maggi, Laura; Capone, Manuela; Vanni, Anna; Lamacchia, Giulia; Bartoli, Lucia; Liotta, Francesco; Cosmi, Lorenzo; Puccini, Benedetta; Nassi, Luca; Sordi, Benedetta; Camerini, Chiara; Vannucchi, Alessandro Maria; Nozzoli, Chiara; Annunziato, Francesco. - In: EUROPEAN JOURNAL OF IMMUNOLOGY. - ISSN 1521-4141. - ELETTRONICO. - 56:(2026), pp. e70123.0-e70123.0. [10.1002/eji.70123]
Downregulation of CD19 Expression Associates With Mantle Cell Lymphoma Relapse Following CAR-T Cell Therapy
Mazzoni, Alessio;Matani, Francesca;Maggi, Laura;Capone, Manuela;Vanni, Anna;Lamacchia, Giulia;Bartoli, Lucia;Liotta, Francesco;Cosmi, Lorenzo;Vannucchi, Alessandro Maria;Annunziato, Francesco
2026
Abstract
We report the case of a stage 4 mantle cell lymphoma patient, resistant to conventional first- and second-line therapies, treated with CAR-T cells. The therapy was initially efficacious, with an appreciable CAR-T cells expansion in vivo. However, downregulation of CD19 expression on malignant B cells led to sudden therapy failure.
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