The 5th edition of the World Health Organization Classification of Tumours (WCT) serves as a foundation for global diagnostic standards in tumour pathology. Similar to other volumes in this series, the Skin Tumours (Skin5) edition follows a standardized approach. This edition introduces two new chapters: ‘Tumours of the nail unit’ and ‘Metastases to skin’, along with new entities across relevant chapters. This review article provides an overview of the updates in Skin5 based on currently published evidence, with emphasis on newly introduced chapters and newly described entities that involve the skin, in particular, epidermal, melanocytic and appendageal tumours.
WHO classification of skin tumours: key updates in the fifth edition / Goldman-Lévy, Gabrielle; Barnhill, Raymond; Bastian, Boris C; Kempf, Werner; Elder, David; Gerami, Pedram; Grayson, Wayne; Kazakov, Dmitry; Massi, Daniela; Messina, Jane; de la Fouchardière, Arnaud; Lazar, Alexander J; Brenn, Thomas; Rous, Brian; Field, Andrew; Gill, Anthony; Hodge, Jennelle C; Khoury, Joseph D; Leite, Katia; Sayed, Shahin; Tan, Puay Hoon; Elenitsas, Rosalie; Calonje, Eduardo; Duncan, Lyn M; Zhiyong, Liang; Moch, Holger; Singh, Rajendra; Wijesinghe, Harshima; Cree, Ian; Lokuhetty, Dilani. - In: HISTOPATHOLOGY. - ISSN 1365-2559. - STAMPA. - 88:(2026), pp. 555-568. [10.1111/his.15562]
WHO classification of skin tumours: key updates in the fifth edition
Massi, Daniela;
2026
Abstract
The 5th edition of the World Health Organization Classification of Tumours (WCT) serves as a foundation for global diagnostic standards in tumour pathology. Similar to other volumes in this series, the Skin Tumours (Skin5) edition follows a standardized approach. This edition introduces two new chapters: ‘Tumours of the nail unit’ and ‘Metastases to skin’, along with new entities across relevant chapters. This review article provides an overview of the updates in Skin5 based on currently published evidence, with emphasis on newly introduced chapters and newly described entities that involve the skin, in particular, epidermal, melanocytic and appendageal tumours.
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