Two novel carbonylchlorido complexes for photodynamic therapy (PDT), RuCOCl and OsCOCl, were synthesized via a unified synthetic strategy. Comparative photophysical, computational and preliminary biological studies reveal the crucial influence of the metal in governing their PDT performance, highlighting the potential of this largely underestimated class of complexes for PDT applications.
Ruthenium or osmium? On the role of the metal in carbonylchlorido complexes for photodynamic therapy / Giacomazzo, GE; Ponte, F; Ceccherini, V; Gianassi, L; Mulas, G; Sicilia, E; Cencetti, F; Valtancoli, B; Conti, L; Giorgi, C. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - ELETTRONICO. - 62:(2026), pp. 3592-3596. [10.1039/d5cc06225j]
Ruthenium or osmium? On the role of the metal in carbonylchlorido complexes for photodynamic therapy
Giacomazzo, GEMembro del Collaboration Group
;Cencetti, FMembro del Collaboration Group
;Valtancoli, BMembro del Collaboration Group
;Giorgi, C
Membro del Collaboration Group
2026
Abstract
Two novel carbonylchlorido complexes for photodynamic therapy (PDT), RuCOCl and OsCOCl, were synthesized via a unified synthetic strategy. Comparative photophysical, computational and preliminary biological studies reveal the crucial influence of the metal in governing their PDT performance, highlighting the potential of this largely underestimated class of complexes for PDT applications.
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