Bevacizumab antibody binds vascular endothelial growth factor (VEGF) inhibiting blood vessels growth, avoiding tumours expansion. During its production, its purification is performed using protein-A affinity chromatography, which highly increases its overall production cost. In this work, an affinity-based precipitation has been designed with a trivalent peptide corresponding to the VEGF epitope that interacts with bevacizumab.
Trivalent Peptide Design for Bevacizumab Salt-Induced Affinity Precipitation / Eloy, Joaquin A.; Barredo-Vacchelli, Gabriela R.; Rodríguez, Jésica A.; Richichi, Barbara; Marradi, Marco; Camperi, Silvia A.. - ELETTRONICO. - (2026), pp. 0-0. ( 6th International Congress on Health Innovation—INOVATEC 2025) [10.3390/proceedings2026137058].
Trivalent Peptide Design for Bevacizumab Salt-Induced Affinity Precipitation
Richichi, Barbara;Marradi, Marco;
2026
Abstract
Bevacizumab antibody binds vascular endothelial growth factor (VEGF) inhibiting blood vessels growth, avoiding tumours expansion. During its production, its purification is performed using protein-A affinity chromatography, which highly increases its overall production cost. In this work, an affinity-based precipitation has been designed with a trivalent peptide corresponding to the VEGF epitope that interacts with bevacizumab.
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