Introduction:Small bowel adenocarcinoma (SBA) and T-cell lymphoma (TCL) are rare but aggressive malignancies associated with celiac disease (CD).Methods:We retrospectively compared 43 CD-associated SBA and 43 CD-associated TCL across international referral centers.Results:CD-associated SBA showed a significantly (p<0.01) better survival than CD-associated TCL. TCL more frequently presented with multifocal involvement and advanced stage, whereas SBA predominantly involved the jejunum. Refractoriness to a gluten-free diet was identified in 70% of TCL, but only in one SBA.Discussion:Our findings demonstrated a worse prognosis of CD-associated TCL in comparison to CD-associated SBA.
Different Survival Outcomes of Small Bowel Adenocarcinomas and T-Cell Lymphomas Associated With Celiac Disease / Santacroce, Giovanni; Vanoli, Alessandro; Aronico, Nicola; Bianchi, Paola Ilaria; Lenti, Marco Vincenzo; Ciacci, Carolina; Zingone, Fabiana; Volta, Umberto; Calabrò, Antonio; Elli, Luca; Ciccocioppo, Rachele; Corazza, Gino Roberto; Lucioni, Marco; Paulli, Marco; Di Sabatino, Antonio; Camilla Guerini, Federica Grillo, Laura Libera, Daniela Furlan, Erica Travaglino, Gabriella Nesi, Gianluca Sampietro, Sandro Ardizzone, Paolo Fociani, Roberto Fiocca, Giovanni Latella, Stefano La Rosa, Antonietta D'Errico, Deborah Malvi, Claudia Mescoli, Massimo Rugge, Stefano Ferrero, Gilberto Poggioli, Fernando Rizzello, Maria Cristina Macciomei, Donatella Santini, Roberto De Giorgio, Giacomo Caio, Maria D'Armiento, Francesco Tonelli, Vincenzo Villanacci, Renato Cannizzaro, Vincenzo Canzonieri, Ada M Florena, Livia Biancone, Giovanni Monteleone, Roberto Caronna, Antonio Ciardi, Flavio Caprioli, Maurizio Vecchi, Renata D'Inca, Anna D'Odorico, Barbara Oreggia, Luca Reggiani Bonetti, Marco Astegiano, Giancarlo Sandri, Marco Silano, Paolo Usai, Vittorio Perfetti, Erica Quaquarini, Antonino G Giannone, Valeria Barresi, Elena Biletta, Andrea Casadei-Gardini, Ombretta Luinetti, Matteo Fassan, Domenico Bagordo, Antonio Lo Bello, Sara Massironi, Roberta Elisa Rossi, Elisa Bossi, Silvia Bolis, Vincenzo L'Imperio, Federico Biagi, Giovanni Arpa, Annick Moens, Gert De Hertog, Marc Ferrante, Rondell P Graham, Jill Swift. - In: THE AMERICAN JOURNAL OF GASTROENTEROLOGY. - ISSN 0002-9270. - STAMPA. - 120:(2025), pp. 10.14309/ajg.0000000000003574.2949-10.14309/ajg.0000000000003574.2953. [10.14309/ajg.0000000000003574]
Different Survival Outcomes of Small Bowel Adenocarcinomas and T-Cell Lymphomas Associated With Celiac Disease
Calabrò, Antonio;Gabriella Nesi;Francesco Tonelli;
2025
Abstract
Introduction:Small bowel adenocarcinoma (SBA) and T-cell lymphoma (TCL) are rare but aggressive malignancies associated with celiac disease (CD).Methods:We retrospectively compared 43 CD-associated SBA and 43 CD-associated TCL across international referral centers.Results:CD-associated SBA showed a significantly (p<0.01) better survival than CD-associated TCL. TCL more frequently presented with multifocal involvement and advanced stage, whereas SBA predominantly involved the jejunum. Refractoriness to a gluten-free diet was identified in 70% of TCL, but only in one SBA.Discussion:Our findings demonstrated a worse prognosis of CD-associated TCL in comparison to CD-associated SBA.
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