Introduction:Small bowel adenocarcinoma (SBA) and T-cell lymphoma (TCL) are rare but aggressive malignancies associated with celiac disease (CD).Methods:We retrospectively compared 43 CD-associated SBA and 43 CD-associated TCL across international referral centers.Results:CD-associated SBA showed a significantly (p<0.01) better survival than CD-associated TCL. TCL more frequently presented with multifocal involvement and advanced stage, whereas SBA predominantly involved the jejunum. Refractoriness to a gluten-free diet was identified in 70% of TCL, but only in one SBA.Discussion:Our findings demonstrated a worse prognosis of CD-associated TCL in comparison to CD-associated SBA.

Different Survival Outcomes of Small Bowel Adenocarcinomas and T-Cell Lymphomas Associated With Celiac Disease / Santacroce, G., Vanoli, A., Aronico, N., Bianchi, P.I., Lenti, M.V., Ciacci, C., Zingone, F., Volta, U., Calabrò, A., Elli, L., Ciccocioppo, R., Corazza, G.R., Lucioni, M., Paulli, M., Di Sabatino, A., Camilla Guerini, F.G.. - In: THE AMERICAN JOURNAL OF GASTROENTEROLOGY. - ISSN 0002-9270. - STAMPA. - 120:(2025), pp. 10.14309/ajg.0000000000003574.2949-10.14309/ajg.0000000000003574.2953. [10.14309/ajg.0000000000003574]

Different Survival Outcomes of Small Bowel Adenocarcinomas and T-Cell Lymphomas Associated With Celiac Disease

Calabrò, Antonio;Gabriella Nesi;Francesco Tonelli;
2025

Abstract

Introduction:Small bowel adenocarcinoma (SBA) and T-cell lymphoma (TCL) are rare but aggressive malignancies associated with celiac disease (CD).Methods:We retrospectively compared 43 CD-associated SBA and 43 CD-associated TCL across international referral centers.Results:CD-associated SBA showed a significantly (p<0.01) better survival than CD-associated TCL. TCL more frequently presented with multifocal involvement and advanced stage, whereas SBA predominantly involved the jejunum. Refractoriness to a gluten-free diet was identified in 70% of TCL, but only in one SBA.Discussion:Our findings demonstrated a worse prognosis of CD-associated TCL in comparison to CD-associated SBA.
2025
120
2949
2953
Goal 3: Good health and well-being
Santacroce, Giovanni; Vanoli, Alessandro; Aronico, Nicola; Bianchi, Paola Ilaria; Lenti, Marco Vincenzo; Ciacci, Carolina; Zingone, Fabiana; Volta, Um...espandi
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1458634
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