We applied ligand-observed NMR strategies to investigate ligand binding to the membrane protein carbonic anhydrase IX (CA IX) in intact human cells. Using an on-cell NMR approach helps overcome the challenges associated with the isolation and purification of membrane proteins.
Characterization Of Ligand Binding To A Membrane Protein By On-Cell NMR Spectroscopy / Love Elizabeth Afolayan, Enrico Luchinat, Letizia Berbieri, and Lucia Banci. - ELETTRONICO. - (2026), pp. 0-0. ( Integrative Structural Biology Meeting Caserta, Italy 4 - 6 March 2026).
Characterization Of Ligand Binding To A Membrane Protein By On-Cell NMR Spectroscopy
Love Elizabeth Afolayan
;Enrico Luchinat;
2026
Abstract
We applied ligand-observed NMR strategies to investigate ligand binding to the membrane protein carbonic anhydrase IX (CA IX) in intact human cells. Using an on-cell NMR approach helps overcome the challenges associated with the isolation and purification of membrane proteins.
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