A 16-year-old girl presenting with calcinosis cutis and localized scleroderma subsequently developed delayed-onset idiopathic inflammatory myopathy five years after initial skin involvement. Despite the absence of typical dermatomyositis features and negative myositis-specific antibodies, whole-body MRI revealed extensive subclinical muscle inflammation. This rare clinical evolution highlights the importance of long-term surveillance in pediatric autoimmune disease and supports the role of imaging in detecting early, atypical manifestations of inflammatory myopathy.
Calcinosis Cutis and Delayed‐Onset Myositis in a Case of Suspected Localized Scleroderma: A Diagnostic and Therapeutic Challenge / Marrani, E., Gatti, L., Pagnini, I., Oranges, T., Filippeschi, C., Simonini, G.. - In: PEDIATRIC DERMATOLOGY. - ISSN 0736-8046. - ELETTRONICO. - (2026), pp. 0-0. [10.1111/pde.70251]
Calcinosis Cutis and Delayed‐Onset Myositis in a Case of Suspected Localized Scleroderma: A Diagnostic and Therapeutic Challenge
Marrani, Edoardo;Gatti, Laura;Pagnini, Ilaria;Oranges, Teresa;Simonini, Gabriele
2026
Abstract
A 16-year-old girl presenting with calcinosis cutis and localized scleroderma subsequently developed delayed-onset idiopathic inflammatory myopathy five years after initial skin involvement. Despite the absence of typical dermatomyositis features and negative myositis-specific antibodies, whole-body MRI revealed extensive subclinical muscle inflammation. This rare clinical evolution highlights the importance of long-term surveillance in pediatric autoimmune disease and supports the role of imaging in detecting early, atypical manifestations of inflammatory myopathy.| File | Dimensione | Formato | |
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