A 16-year-old girl presenting with calcinosis cutis and localized scleroderma subsequently developed delayed-onset idiopathic inflammatory myopathy five years after initial skin involvement. Despite the absence of typical dermatomyositis features and negative myositis-specific antibodies, whole-body MRI revealed extensive subclinical muscle inflammation. This rare clinical evolution highlights the importance of long-term surveillance in pediatric autoimmune disease and supports the role of imaging in detecting early, atypical manifestations of inflammatory myopathy.
Calcinosis Cutis and Delayed‐Onset Myositis in a Case of Suspected Localized Scleroderma: A Diagnostic and Therapeutic Challenge / Marrani, Edoardo; Gatti, Laura; Pagnini, Ilaria; Oranges, Teresa; Filippeschi, Cesare; Simonini, Gabriele. - In: PEDIATRIC DERMATOLOGY. - ISSN 0736-8046. - ELETTRONICO. - (2026), pp. 0-0. [10.1111/pde.70251]
Calcinosis Cutis and Delayed‐Onset Myositis in a Case of Suspected Localized Scleroderma: A Diagnostic and Therapeutic Challenge
Marrani, Edoardo;Gatti, Laura;Pagnini, Ilaria;Oranges, Teresa;Filippeschi, Cesare;Simonini, Gabriele
2026
Abstract
A 16-year-old girl presenting with calcinosis cutis and localized scleroderma subsequently developed delayed-onset idiopathic inflammatory myopathy five years after initial skin involvement. Despite the absence of typical dermatomyositis features and negative myositis-specific antibodies, whole-body MRI revealed extensive subclinical muscle inflammation. This rare clinical evolution highlights the importance of long-term surveillance in pediatric autoimmune disease and supports the role of imaging in detecting early, atypical manifestations of inflammatory myopathy.I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.



