Glycopeptides of hMOG(30-50) containing a glucosyl moiety on the side- chains of Asn, Ser or Hyp at position 31 were synthesised. Antibody titres to hMOG(30-50) and to its glucoderivatives were measured by ELISA in sera of patients affected by different neurological diseases. Anti-hMOG(30-50) antibodies were detected only using the glycopeptide [Asn31(N-Glc)]hMOG(30- 50).
A synthetic glycopeptide of human myelin oligodendrocyte glycoprotein to detect antibody responses in multiple sclerosis and other neurological diseases / Mazzucco, S., Matà, S., Vergelli, M., Fioresi, R., Nardi, E., Mazzanti, B., Chelli, M., Lolli, F., Ginanneschi, M., Pinto, F., Massacesi, L., Papini, A.M.. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - STAMPA. - 9:(1999), pp. 167-172. [10.1016/s0960-894x(98)00698-2]
A synthetic glycopeptide of human myelin oligodendrocyte glycoprotein to detect antibody responses in multiple sclerosis and other neurological diseases
Mazzucco, Silvia;Vergelli, Marco;Nardi, Elena;Mazzanti, Benedetta;Chelli, Mario;Lolli, Francesco;Ginanneschi, Mauro;Pinto, Francesco;Massacesi, Luca;Papini, Anna Maria
1999
Abstract
Glycopeptides of hMOG(30-50) containing a glucosyl moiety on the side- chains of Asn, Ser or Hyp at position 31 were synthesised. Antibody titres to hMOG(30-50) and to its glucoderivatives were measured by ELISA in sera of patients affected by different neurological diseases. Anti-hMOG(30-50) antibodies were detected only using the glycopeptide [Asn31(N-Glc)]hMOG(30- 50).
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