Expression And NMR Characterization Of Labelled P-domains Of Emerging Norovirus

The ability of norovirus to infect host cells depends on the interaction between the Protruding domain (P domain) of its capsid protein VP1 and Histo-Blood Group Antigens (HBGAs) on the surface of host cells. Furthermore, previous cell-based studies found, that Human Milk Oligosaccharides (HMOs) prevent norovirus infection to cells, by acting as a decoy receptor and blocking the interaction between HBGAs and human noroviruses. Therefore, understanding the structure of the P domain is essential for the development of effective antiviral drugs and vaccines.