The accumulation of misfolded transactive response DNA-binding protein 43 (TDP-43) in the brain is a hallmark of several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). This project aims to investigate the factors influencing the kinetics of aggregation of the C-terminal domain of TDP-43 (CTD-TDP-43). In particular, we will examine the effect of the small molecule ANLE138b1 on the aggregation process.
INTERFERING THE AGGREGATION PROCESS OF THE C-TERMINAL DOMAIN OF TDP-43 / Bianca Susini, T.S.. - ELETTRONICO. - (2026), pp. 1-1. (ADPD 2026 ).
INTERFERING THE AGGREGATION PROCESS OF THE C-TERMINAL DOMAIN OF TDP-43
Bianca Susini;Tommaso Staderini;Elisa Guerra;Linda Cerofolini
;Marco Fragai
2026
Abstract
The accumulation of misfolded transactive response DNA-binding protein 43 (TDP-43) in the brain is a hallmark of several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). This project aims to investigate the factors influencing the kinetics of aggregation of the C-terminal domain of TDP-43 (CTD-TDP-43). In particular, we will examine the effect of the small molecule ANLE138b1 on the aggregation process.
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