This work investigates the specific contributions of the GrxA, GrxB, and Trx domains of human glutaredoxin-3 (GLRX3) in [4Fe-4S] cluster assembly on NUBP1. The findings reveal that cooperative action between GrxA and GrxB is required for functional dimerization of GLRX3 and efficient cluster transfer to NUBP1, whereas the N-terminal Trx domain is dispensable under in vitro conditions.
Human glutaredoxin 3: multiple domains for a unique function / Rosanna Cuccaro, Martina Masini, MALANHO DA SILVA JOSE PEDRO, Francesca Camponeschi, Lucia Banci. - In: JOURNAL OF INORGANIC BIOCHEMISTRY. - ISSN 0162-0134. - ELETTRONICO. - (2025), pp. 0-0.
Human glutaredoxin 3: multiple domains for a unique function
Rosanna Cuccaro;Martina Masini;MALANHO DA SILVA JOSE PEDRO;Francesca Camponeschi
;Lucia Banci
2025
Abstract
This work investigates the specific contributions of the GrxA, GrxB, and Trx domains of human glutaredoxin-3 (GLRX3) in [4Fe-4S] cluster assembly on NUBP1. The findings reveal that cooperative action between GrxA and GrxB is required for functional dimerization of GLRX3 and efficient cluster transfer to NUBP1, whereas the N-terminal Trx domain is dispensable under in vitro conditions.
| File | Dimensione | Formato | |
|---|---|---|---|
|
Human glutaredoxin 3 multiple domains for a unique function.docx
Accesso chiuso
Tipologia:
Versione finale referata (Postprint, Accepted manuscript)
Licenza:
Tutti i diritti riservati
Dimensione
617.35 kB
Formato
Microsoft Word XML
|
617.35 kB | Microsoft Word XML | Richiedi una copia all'autore |
I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
