This study investigates the role of the GLRX3-BOLA2 complex in [2Fe-2S] cluster transfer to the CIA scaffold protein NUBP1. The results show that both GLRX3 and GLRX3-BOLA2 support the formation of the same canonical [4Fe-4S] cluster with comparable transfer efficiency, while BOLA2 may contribute to cluster stabilization by modulating electron transfer under specific cellular conditions.
Alternative [2Fe-2S] donor assemblies in the cytosol: GLRX3 and GLRX3-BOLA2 converge on NUBP1 maturation / Martina Masini, Rosanna Cuccaro, Lucia Banci. - In: THE FEBS JOURNAL. - ISSN 1742-4658. - ELETTRONICO. - (2026), pp. 0-0.
Alternative [2Fe-2S] donor assemblies in the cytosol: GLRX3 and GLRX3-BOLA2 converge on NUBP1 maturation
Martina Masini;Rosanna Cuccaro;Lucia Banci
2026
Abstract
This study investigates the role of the GLRX3-BOLA2 complex in [2Fe-2S] cluster transfer to the CIA scaffold protein NUBP1. The results show that both GLRX3 and GLRX3-BOLA2 support the formation of the same canonical [4Fe-4S] cluster with comparable transfer efficiency, while BOLA2 may contribute to cluster stabilization by modulating electron transfer under specific cellular conditions.
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