Genetic variability in ADAM17/TACE is associated with sporadic Alzheimer’s disease risk, neuropsychiatric symptoms and cognitive performance on the Rey Auditory Verbal Learning and Clock Drawing Tests

Bruno, Francesco; Aceto, Mirella A.; Paparazzo, Ersilia; Arcuri, Domenico; Vozzo, Francesca; Mirante, Serena; Greco, Beatrice M.; Serra Cassano, Teresa; Abondio, Paolo; Canterini, Sonia; Malvaso, Antonio; Grecucci, Alessandro; Citrigno, Luigi; Geracitano, Silvana; Spadafora, Patrizia; Puccio, Gianfranco; Frangipane, Francesca; Curcio, Sabrina M.; Ferrise, Francesca; Laganà, Valentina; Colao, Rosanna; Passarino, Giuseppe; Bruni, Amalia C.; Maletta, Raffaele; Cavalcanti, Francesca; Montesanto, Alberto

doi:10.1371/journal.pone.0309631

This study demonstrates that genetic variations in the ADAM17/TACE gene are associated with sporadic Alzheimer’s disease risk in an Italian cohort. The research links specific single nucleotide polymorphisms to neuropsychiatric symptoms and cognitive performance deficits. For more information, visit the study's source.

Genetic variability in ADAM17/TACE is associated with sporadic Alzheimer’s disease risk, neuropsychiatric symptoms and cognitive performance on the Rey Auditory Verbal Learning and Clock Drawing Tests / Bruno, F., Aceto, M.A., Paparazzo, E., Arcuri, D., Vozzo, F., Mirante, S., Greco, B.M., Serra Cassano, T., Abondio, P., Canterini, S., Malvaso, A., Grecucci, A., Citrigno, L., Geracitano, S., Spadafora, P., Puccio, G., Frangipane, F., Curcio, S.M., Ferrise, F., Laganà, V., et al.. - In: PLOS ONE. - ISSN 1932-6203. - ELETTRONICO. - 20:(2025), pp. 0-0. [10.1371/journal.pone.0309631]