Nucleophilic aromatic substitutions on 4,5-dicyanopyridazine: Application of bis-nucleophiles

This work investigates the reactivity of 4,5-dicyanopyridazine as a heterocyclic electrophile towards different bis-nucleophiles. The study explores nucleophilic aromatic substitution and related reaction pathways, demonstrating the synthesis of functionalized and fused polycyclic pyridazine derivatives under mild reaction conditions. The results highlight the versatility of this approach for the preparation of nitrogen-containing heterocyclic compounds.