Determining the incubation period of Oropouche virus disease can inform clinical and public health practice. We analyzed data from 97 travel-associated cases identifi by the Centers for Disease Control and Prevention (n = 74) or the GeoSentinel Network (n = 13) and 10 cases from published literature. Using log-normal interval-censored survival analysis, we estimated the median incubation period to be 3.2 (95% CI 2.5–3.9) days. Symptoms developed by 1.1 (95% CI 0.6–1.5) days for 5% of patients, 9.7 (95%CI 6.9–12.5) days for 95% of patients, and 15.4 (95% CI 9.6–21.3) days for 99% of patients. The estimated incubation period range of 1–10 days can be used to assess timing and potential source of exposure in patients with Oropouche symptoms. For patients with symptom onset >2 weeks after return from travel, clinicians and public health responders should consider the possibility of local vectorborne transmission or alternative modes of transmission.
Estimation of Incubation Period for Oropouche Virus Disease among Travel-Associated Cases, 2024–2025 / Guagliardo S.A.J., Martin S., Gould C.V., Sutter R., Jacobs D., O'Laughlin K., Huits R., Castilletti C., Staples J.E., Alcedo S., Asgeirsson H., Barbiero A., Beig I., Bottieau E., Brett-Major D., Buckley R.D.M., Denkinger C., Glans H., Gobbi F., Hamer D., et al.. - In: EMERGING INFECTIOUS DISEASES. - ISSN 1080-6040. - ELETTRONICO. - 31:(2025), pp. 1337-1343. [10.3201/eid3107.250468]
Estimation of Incubation Period for Oropouche Virus Disease among Travel-Associated Cases, 2024–2025
Barbiero A.;Zammarchi L.
2025
Abstract
Determining the incubation period of Oropouche virus disease can inform clinical and public health practice. We analyzed data from 97 travel-associated cases identifi by the Centers for Disease Control and Prevention (n = 74) or the GeoSentinel Network (n = 13) and 10 cases from published literature. Using log-normal interval-censored survival analysis, we estimated the median incubation period to be 3.2 (95% CI 2.5–3.9) days. Symptoms developed by 1.1 (95% CI 0.6–1.5) days for 5% of patients, 9.7 (95%CI 6.9–12.5) days for 95% of patients, and 15.4 (95% CI 9.6–21.3) days for 99% of patients. The estimated incubation period range of 1–10 days can be used to assess timing and potential source of exposure in patients with Oropouche symptoms. For patients with symptom onset >2 weeks after return from travel, clinicians and public health responders should consider the possibility of local vectorborne transmission or alternative modes of transmission.
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