We investigated the structural and functional consequences of chronic mavacamten exposure using human induced pluripotent stem cell–derived cardiomyocytes (hiPSC-CMs) and engineered heart tissues (EHTs) generated from an HCM MYBPC3:c.772G A hiPSC line (ID3)
Long-term mavacamten exposure reduces force and sarcomere density in a human induced pluripotent stem cell-derived model of hypertrophic cardiomyopathy / Langione, M., Giammarino, L., Semeraro, R., Scellini, B., Steczina, S., Spinelli, V., Martelli, E., Della Corte, I., Olianti, C., Magi, A., Sacconi, L., Cerbai, E., Regnier, M., Olivotto, I., Tesi, C., Poggesi, C., Coppini, R., Ferrantini, C., Pioner, J.M.. - In: CARDIOVASCULAR RESEARCH. - ISSN 1755-3245. - ELETTRONICO. - 122:(2026), pp. 1732-1735. [10.1093/cvr/cvag159]
Long-term mavacamten exposure reduces force and sarcomere density in a human induced pluripotent stem cell-derived model of hypertrophic cardiomyopathy
Langione, Marianna;Giammarino, Lucrezia;Semeraro, Roberto;Scellini, Beatrice;Spinelli, Valentina;Martelli, Elema;Della Corte, Irma;Olianti, Camilla;Magi, Alberto;Sacconi, Leonardo;Cerbai, Elisabetta;Regnier, Michael;Olivotto, Iacopo;Tesi, Chiara;Poggesi, Corrado;Coppini, Raffaele;Ferrantini, Cecilia;
2026
Abstract
We investigated the structural and functional consequences of chronic mavacamten exposure using human induced pluripotent stem cell–derived cardiomyocytes (hiPSC-CMs) and engineered heart tissues (EHTs) generated from an HCM MYBPC3:c.772G A hiPSC line (ID3)
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