Noninvasive Characterization of Myocardial Diseases With Hypertrophic Phenotypes Using Integrated ECG/Echocardiographic Indices

Allegro, Valentina; Pagura, Linda; Porcari, Aldostefano; Barbati, Giulia; Longhi, Simone; Musumeci, Beatrice; Cipriani, Alberto; Canepa, Marco; Chimenti, Cristina; Lillo, Rosa; Graziani, Francesca; Bonacchi, Giacomo; Argiro, Alessia; Zampieri, Mattia; Chiti, Chiara; Ruotolo, Irene; Tini, Giacomo; De Michieli, Laura; Sinigiani, Giulio; Di Bella, Gianluca; Labate, Marianna Eleonora; Eustachi, Virginia; Cianci, Alessio; Sammartino, Aniello; Olivotto, Iacopo; Biagini, Elena; Sinagra, Gianfranco; Merlo, Marco; Cappelli, Francesco

doi:10.1161/JAHA.125.043647

BACKGROUND: Indices reflecting the discordance between QRS complex voltages on ECG and left ventricular (LV) wall thickness or LV mass index on echocardiogram (echo) have enabled identification of cardiac amyloidosis (CA) among patients with hypertrophic hearts. However, this evidence comes from studies that have excluded patients with established hypertrophic cardiomyopathy (HCM) and Anderson-Fabry disease (AFD). The aim of this study was to assess the performance of ECG/ echo indices in characterizing adult patients with cardiomyopathies and hypertrophic phenotype.

Noninvasive Characterization of Myocardial Diseases With Hypertrophic Phenotypes Using Integrated ECG/Echocardiographic Indices / Allegro, V., Pagura, L., Porcari, A., Barbati, G., Longhi, S., Musumeci, B., Cipriani, A., Canepa, M., Chimenti, C., Lillo, R., Graziani, F., Bonacchi, G., Argiro, A., Zampieri, M., Chiti, C., Ruotolo, I., Tini, G., De Michieli, L., Sinigiani, G., Di Bella, G., et al.. - In: JOURNAL OF THE AMERICAN HEART ASSOCIATION. CARDIOVASCULAR AND CEREBROVASCULAR DISEASE. - ISSN 2047-9980. - ELETTRONICO. - 15:(2026), pp. e043647.0-e043647.0. [10.1161/JAHA.125.043647]