In this retrospective, observational study, 45 patients with AFD underwent CMR with T1 mapping using shortened modified Look-Locker inversion recovery sequences, 2-dimensional echocardiography, and quantification of Mainz Severity Score Index (MSSI). Patients were divided into 3 groups (n = 15 each) with increasing severity: 1) normal T1, no LVH; 2) low T1, no LVH; and 3) LVH. Patients were compared with 15 healthy control subjects. CMR-FT was applied for the analysis of LA strain (total, conduit, booster) and volumes. Univariate regression analysis showed a significant association between LA total strain and age, native septal T1, and MSSI but not with sex or presence of “classic” mutations.
Atrial Dysfunction Assessed by Cardiac Magnetic Resonance as an Early Marker of Fabry Cardiomyopathy / Bernardini A., Camporeale A., Pieroni M., Pieruzzi F., Figliozzi S., Lusardi P., Spada M., Mignani R., Burlina A., Carubbi F., Battaglia Y., Graziani F., Pica S., Tondi L., Chow K., Boveri S., Olivotto I., Lombardi M.. - In: JACC. CARDIOVASCULAR IMAGING. - ISSN 1936-878X. - ELETTRONICO. - 13:(2020), pp. 2262-2264. [10.1016/j.jcmg.2020.05.011]
Atrial Dysfunction Assessed by Cardiac Magnetic Resonance as an Early Marker of Fabry Cardiomyopathy
Pieroni M.;Mignani R.;Graziani F.;Olivotto I.;
2020
Abstract
In this retrospective, observational study, 45 patients with AFD underwent CMR with T1 mapping using shortened modified Look-Locker inversion recovery sequences, 2-dimensional echocardiography, and quantification of Mainz Severity Score Index (MSSI). Patients were divided into 3 groups (n = 15 each) with increasing severity: 1) normal T1, no LVH; 2) low T1, no LVH; and 3) LVH. Patients were compared with 15 healthy control subjects. CMR-FT was applied for the analysis of LA strain (total, conduit, booster) and volumes. Univariate regression analysis showed a significant association between LA total strain and age, native septal T1, and MSSI but not with sex or presence of “classic” mutations.
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