JAK2 V617F (JAK2) is the most frequent driver mutation in myeloproliferative neoplasms (MPN), but it was found in healthy individuals with clonal hematopoiesis of indeterminate potential (CHIP), though its role in CHIP remains debated (Leukemia 2021;35(9):2706-2709). We examined clinical, genetic, and morphological features in suspected MPN cases with JAK2 VAF <2%.
CO60 | One hundred suspected myeloproliferative neoplasms with a JAK2 v617f variant allele frequency <2%: clinical, genetic and histopathological correlates / Loscocco, G.G.. - In: HAEMATOLOGICA. - ISSN 1592-8721. - ELETTRONICO. - 111:(2026), pp. 0-0. [10.3324/haematol.2026.s1.63]
CO60 | One hundred suspected myeloproliferative neoplasms with a JAK2 v617f variant allele frequency <2%: clinical, genetic and histopathological correlates
Loscocco;Giuseppe Gaetano;A. M. Vannucchi
2026
Abstract
JAK2 V617F (JAK2) is the most frequent driver mutation in myeloproliferative neoplasms (MPN), but it was found in healthy individuals with clonal hematopoiesis of indeterminate potential (CHIP), though its role in CHIP remains debated (Leukemia 2021;35(9):2706-2709). We examined clinical, genetic, and morphological features in suspected MPN cases with JAK2 VAF <2%.
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