FLORE (FLOrence REsearch) è il repository istituzionale ad accesso pieno e aperto dell'Università degli Studi di Firenze.
Raccoglie, documenta e conserva le informazioni sulla produzione scientifica dell'Università e costituisce l'Anagrafe della ricerca dell'Ateneo.
EnglishThe effect produced by repeated administration of the HI-antihistaminics diphenhydramine, promethazine and pyrilamine on their ability to induce antinociception was evaluated :Ln the mouse hot-plate and abdominal constriction tests. Contrary to morphine, baclofen and oxotremorine, the three HI antagonists investigated did not promote the devetopment of tolerance to the analgesiceffect after 14 days of repeated treatment. HI antagonists, could, therefore, represent a promising pharmacological approach to the management of chronic Ipain
| Titolo: | NO DEVELOPMENT OF TOLERANCE TO ANALGESIA BY REPEATED ADMINISTRATION OF H1 ANTAGONISTS |
| Autori di Ateneo: | |
| Autori: | GHELARDINI, CARLA; GALEOTTI, NICOLETTA; BARTOLINI, ALESSANDRO |
| Anno di registrazione: | 1998 |
| Rivista: | |
| Volume: | 63 |
| Pagina iniziale: | PL317 |
| Pagina finale: | PL322 |
| Abstract: | The effect produced by repeated administration of the HI-antihistaminics diphenhydramine, promethazine and pyrilamine on their ability to induce antinociception was evaluated :Ln the mouse hot-plate and abdominal constriction tests. Contrary to morphine, baclofen and oxotremorine, the three HI antagonists investigated did not promote the devetopment of tolerance to the analgesiceffect after 14 days of repeated treatment. HI antagonists, could, therefore, represent a promising pharmacological approach to the management of chronic Ipain |
| Handle: | http://hdl.handle.net/2158/15883 |
| Appare nelle tipologie: | 1a - Articolo su rivista |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| 32.Life Sci.pdf | Versione Finale Referata | Open Access | Accesso pubblicoVisualizza/Apri |
http://hdl.handle.net/2158/15883
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