The effect produced by repeated administration of the HI-antihistaminics diphenhydramine, promethazine and pyrilamine on their ability to induce antinociception was evaluated :Ln the mouse hot-plate and abdominal constriction tests. Contrary to morphine, baclofen and oxotremorine, the three HI antagonists investigated did not promote the devetopment of tolerance to the analgesiceffect after 14 days of repeated treatment. HI antagonists, could, therefore, represent a promising pharmacological approach to the management of chronic Ipain
NO DEVELOPMENT OF TOLERANCE TO ANALGESIA BY REPEATED ADMINISTRATION OF H1 ANTAGONISTS / C. GHELARDINI; N. GALEOTTI; A. BARTOLINI. - In: LIFE SCIENCES. - ISSN 0024-3205. - STAMPA. - 63:(1998), pp. PL317-PL322. [10.1016/S0024-3205(98)00483-4]
NO DEVELOPMENT OF TOLERANCE TO ANALGESIA BY REPEATED ADMINISTRATION OF H1 ANTAGONISTS
GHELARDINI, CARLA;GALEOTTI, NICOLETTA;BARTOLINI, ALESSANDRO
1998
Abstract
The effect produced by repeated administration of the HI-antihistaminics diphenhydramine, promethazine and pyrilamine on their ability to induce antinociception was evaluated :Ln the mouse hot-plate and abdominal constriction tests. Contrary to morphine, baclofen and oxotremorine, the three HI antagonists investigated did not promote the devetopment of tolerance to the analgesiceffect after 14 days of repeated treatment. HI antagonists, could, therefore, represent a promising pharmacological approach to the management of chronic Ipain
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