NO DEVELOPMENT OF TOLERANCE TO ANALGESIA BY REPEATED ADMINISTRATION OF H1 ANTAGONISTS

Ghelardini, C.; Galeotti, N.; Bartolini, A.

doi:10.1016/S0024-3205(98)00483-4

The effect produced by repeated administration of the HI-antihistaminics diphenhydramine, promethazine and pyrilamine on their ability to induce antinociception was evaluated :Ln the mouse hot-plate and abdominal constriction tests. Contrary to morphine, baclofen and oxotremorine, the three HI antagonists investigated did not promote the devetopment of tolerance to the analgesiceffect after 14 days of repeated treatment. HI antagonists, could, therefore, represent a promising pharmacological approach to the management of chronic Ipain

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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2158/15883

Titolo:	NO DEVELOPMENT OF TOLERANCE TO ANALGESIA BY REPEATED ADMINISTRATION OF H1 ANTAGONISTS
Autori interni:	GHELARDINI, CARLA GALEOTTI, NICOLETTA BARTOLINI, ALESSANDRO
Autori:	C. GHELARDINI; N. GALEOTTI; A. BARTOLINI
Data di pubblicazione:	1998
Rivista:	LIFE SCIENCES
Volume:	63
Pagina iniziale:	PL317
Pagina finale:	PL322
Abstract:	The effect produced by repeated administration of the HI-antihistaminics diphenhydramine, promethazine and pyrilamine on their ability to induce antinociception was evaluated :Ln the mouse hot-plate and abdominal constriction tests. Contrary to morphine, baclofen and oxotremorine, the three HI antagonists investigated did not promote the devetopment of tolerance to the analgesiceffect after 14 days of repeated treatment. HI antagonists, could, therefore, represent a promising pharmacological approach to the management of chronic Ipain
Handle:	http://hdl.handle.net/2158/15883
Appare nelle tipologie:	1a - Articolo su rivista

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