The effects of the administration of different 5-HT4 receptor antagonists (SDZ 205557, GR 125487) and 5-HT4 receptor agonists (BIMU 1, BIMU 8) on memory processes were evaluated in the mouse passive avoidance test. The administration of SDZ 205557 (10 mg kg21 i.p.) and GR 125487 (10 mg kg21 i.p.) immediately after termination of the training session produced an amnesic effect. BIMU 1 (20 mg kg21 i.p.) and BIMU 8 (30 mg kg21 i.p.), administered 20 min before the training session, prevented the 5-HT4 receptor antagonist-induced amnesia. In the same experimental conditions BIMU 1 (10 mg kg21 i.p.; 25 mg/mouse intracerebroventricularly) and BIMU 8 (30 mg kg21 i.p.; 30 mg per mouse intracerebroventricularly) prevented scopolamine (1 mg kg21 i.p.) and dicyclomine (2 mg kg21 i.p.) amnesia and, at the dose of 10 and 30 mg kg21 i.p. respectively, prevented amnesia induced by exposure to a hypoxic environment. At the highest effective doses, none of the drugs impaired motor coordination, as revealed by the rota rod test, or modified spontaneous motility and inspection activity, as revealed by the hole board and Animex tests. The 5-HT3 antagonist ondansetron (0.1–1 mg kg21 i.p.) was unable to prevent scopolamine-, 5-HT4 antagonist- and hypoxia-induced amnesia. These results suggest that the modulation of 5-HT4 receptors plays an important role in the regulation of memory processes. On these bases, the 5-HT4 receptor agonists could be useful in the treatment of cognitive deficits although 5-HT4 receptor antagonists may represent pharmacological tools for investigation of new potential antiamnesic drugs.

ROLE OF 5-HT4 RECEPTORS IN THE MOUSE PASSIVE AVOIDANCE TEST / N. GALEOTTI; C. GHELARDINI; A. BARTOLINI. - In: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. - ISSN 0022-3565. - STAMPA. - 286:(1998), pp. 1115-1121.

ROLE OF 5-HT4 RECEPTORS IN THE MOUSE PASSIVE AVOIDANCE TEST

GALEOTTI, NICOLETTA;GHELARDINI, CARLA;BARTOLINI, ALESSANDRO
1998

Abstract

The effects of the administration of different 5-HT4 receptor antagonists (SDZ 205557, GR 125487) and 5-HT4 receptor agonists (BIMU 1, BIMU 8) on memory processes were evaluated in the mouse passive avoidance test. The administration of SDZ 205557 (10 mg kg21 i.p.) and GR 125487 (10 mg kg21 i.p.) immediately after termination of the training session produced an amnesic effect. BIMU 1 (20 mg kg21 i.p.) and BIMU 8 (30 mg kg21 i.p.), administered 20 min before the training session, prevented the 5-HT4 receptor antagonist-induced amnesia. In the same experimental conditions BIMU 1 (10 mg kg21 i.p.; 25 mg/mouse intracerebroventricularly) and BIMU 8 (30 mg kg21 i.p.; 30 mg per mouse intracerebroventricularly) prevented scopolamine (1 mg kg21 i.p.) and dicyclomine (2 mg kg21 i.p.) amnesia and, at the dose of 10 and 30 mg kg21 i.p. respectively, prevented amnesia induced by exposure to a hypoxic environment. At the highest effective doses, none of the drugs impaired motor coordination, as revealed by the rota rod test, or modified spontaneous motility and inspection activity, as revealed by the hole board and Animex tests. The 5-HT3 antagonist ondansetron (0.1–1 mg kg21 i.p.) was unable to prevent scopolamine-, 5-HT4 antagonist- and hypoxia-induced amnesia. These results suggest that the modulation of 5-HT4 receptors plays an important role in the regulation of memory processes. On these bases, the 5-HT4 receptor agonists could be useful in the treatment of cognitive deficits although 5-HT4 receptor antagonists may represent pharmacological tools for investigation of new potential antiamnesic drugs.
286
1115
1121
N. GALEOTTI; C. GHELARDINI; A. BARTOLINI
File in questo prodotto:
File Dimensione Formato  
30.JPET 5-HT4 memory.pdf

accesso aperto

Tipologia: Versione finale referata (Postprint, Accepted manuscript)
Licenza: Open Access
Dimensione 581.33 kB
Formato Adobe PDF
581.33 kB Adobe PDF Visualizza/Apri

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2158/15993
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 74
  • ???jsp.display-item.citation.isi??? 68
social impact