The antinociceptive effects of the 5-HT1A agonists buspirone [3 mg/kg intraperitoneally (IP)], gepirone (3–6 mg/kg IP), and 8-OH-DPAT [3–5 mg/kg IP; 1–3 mg per mouse intracerebroventricularly (ICV)] were examined in mice by using the hot-plate (thermal stimulus) and abdominal constriction (chemical stimulus) tests. Buspirone, gepirone, and 8-OH-DPAT produced significant antinociception, which was prevented by atropine (5 mg/kg IP), the ACh depletor hemicholinium-3 (1mg per mouse ICV), and the 5-HT1A antagonist NAN 190 (0.5mg per mouse ICV), but not by naloxone (1 mg/kg IP), the GABAB antagonist CGP 35348 (100 mg/kg IP), and pertussis toxin (0.25 mg per mouse ICV). NAN 190, which totally antagonized buspirone, gepirone, and 8-OH-DPAT antinociception, did not modify the analgesic effect of morphine (5 mg/kg subcutaneously). In the antinociceptive dose range, none of the 5HT1A agonists impaired mouse performance evaluated by rota-rod and hole board tests. On the basis of these data, it can be postulated that buspirone, gepirone, and 8-OH-DPAT exert an antinociceptive effect mediated by a central amplification of cholinergic transmission.
5-HT1A AGONISTS INDUCE CENTRAL CHOLINERGIC ANTINOCICEPTION / N. GALEOTTI; C. GHELARDINI; A. BARTOLINI. - In: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR. - ISSN 0091-3057. - STAMPA. - 57:(1997), pp. 835-841. [10.1016/S0091-3057(96)00401-7]
5-HT1A AGONISTS INDUCE CENTRAL CHOLINERGIC ANTINOCICEPTION
GALEOTTI, NICOLETTA;GHELARDINI, CARLA;BARTOLINI, ALESSANDRO
1997
Abstract
The antinociceptive effects of the 5-HT1A agonists buspirone [3 mg/kg intraperitoneally (IP)], gepirone (3–6 mg/kg IP), and 8-OH-DPAT [3–5 mg/kg IP; 1–3 mg per mouse intracerebroventricularly (ICV)] were examined in mice by using the hot-plate (thermal stimulus) and abdominal constriction (chemical stimulus) tests. Buspirone, gepirone, and 8-OH-DPAT produced significant antinociception, which was prevented by atropine (5 mg/kg IP), the ACh depletor hemicholinium-3 (1mg per mouse ICV), and the 5-HT1A antagonist NAN 190 (0.5mg per mouse ICV), but not by naloxone (1 mg/kg IP), the GABAB antagonist CGP 35348 (100 mg/kg IP), and pertussis toxin (0.25 mg per mouse ICV). NAN 190, which totally antagonized buspirone, gepirone, and 8-OH-DPAT antinociception, did not modify the analgesic effect of morphine (5 mg/kg subcutaneously). In the antinociceptive dose range, none of the 5HT1A agonists impaired mouse performance evaluated by rota-rod and hole board tests. On the basis of these data, it can be postulated that buspirone, gepirone, and 8-OH-DPAT exert an antinociceptive effect mediated by a central amplification of cholinergic transmission.File | Dimensione | Formato | |
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