Abstract: We studied the effect of heparin on proliferation and signalling in normal NIH/3T3 fibroblasts, and in cells transformed by different oncogenes. Heparin inhibited the proliferation of normal as well as of v-sis and v-erbB transformed fibroblasts in the presence of serum, but failed to inhibit v-erbB-driven proliferation in serum-starved cultures; under these conditions, heparin inhibited by approximately 50% the proliferation of normal and v-sis- transformed cells. Heparin also inhibited PDGF-induced cell proliferation and inositol lipid turnover in v-sis transformants, but it did not affect PDGF mitogenic signalling in NIH/3T3 fibroblasts.

Antiproliferative effects of heparin on normal and transformed NIH/3T3 fibroblasts / S. CAVARI;M. RUGGIERO;S. VANNUCCHI. - In: CELL BIOLOGY INTERNATIONAL. - ISSN 1065-6995. - STAMPA. - 17:(1993), pp. 781-786.

Antiproliferative effects of heparin on normal and transformed NIH/3T3 fibroblasts

RUGGIERO, MARCO;VANNUCCHI, SIMONETTA
1993

Abstract

Abstract: We studied the effect of heparin on proliferation and signalling in normal NIH/3T3 fibroblasts, and in cells transformed by different oncogenes. Heparin inhibited the proliferation of normal as well as of v-sis and v-erbB transformed fibroblasts in the presence of serum, but failed to inhibit v-erbB-driven proliferation in serum-starved cultures; under these conditions, heparin inhibited by approximately 50% the proliferation of normal and v-sis- transformed cells. Heparin also inhibited PDGF-induced cell proliferation and inositol lipid turnover in v-sis transformants, but it did not affect PDGF mitogenic signalling in NIH/3T3 fibroblasts.
1993
17
781
786
S. CAVARI;M. RUGGIERO;S. VANNUCCHI
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/16112
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