The possible association between radon exposure in dwellings and adult myeloid leukaemia had been explored in an Italian province by a case-control study. A total of 44 cases and 211 controls were selected from death certificates file. No association had been found in the original study (OR =0.58 for >185 vs <=80Bq/cm). Here we reanalyse the data taking into account the measurement error of radon concentration and the presence of missing data. A Bayesian hierarchical model with error in covariates is proposed which allows appropriate imputation of missing values. The general conclusion of no evidence of association with radon does not change, but a negative association is not observed anymore (OR =0:99 for ¿185 vs 680Bq=cm). After adjusting for residential house radon and gamma radiation, and for the multilevel data structure, geological features of the soil is associated with adult myeloid leukaemia risk (OR =2:14; 95 per cent Cr.I. 1.0–5.5).

Adult Myeloid Leukaemia and Radon Exposure: a Bayesian Model for a Case-Control Study with Error in Covariates / S. TOTI; A. BIGGERI; F. FORASTIERE. - In: STATISTICS IN MEDICINE. - ISSN 0277-6715. - STAMPA. - 24(12)(2005), pp. 1849-1864.

Adult Myeloid Leukaemia and Radon Exposure: a Bayesian Model for a Case-Control Study with Error in Covariates

TOTI, SIMONA;BIGGERI, ANNIBALE;
2005

Abstract

The possible association between radon exposure in dwellings and adult myeloid leukaemia had been explored in an Italian province by a case-control study. A total of 44 cases and 211 controls were selected from death certificates file. No association had been found in the original study (OR =0.58 for >185 vs <=80Bq/cm). Here we reanalyse the data taking into account the measurement error of radon concentration and the presence of missing data. A Bayesian hierarchical model with error in covariates is proposed which allows appropriate imputation of missing values. The general conclusion of no evidence of association with radon does not change, but a negative association is not observed anymore (OR =0:99 for ¿185 vs 680Bq=cm). After adjusting for residential house radon and gamma radiation, and for the multilevel data structure, geological features of the soil is associated with adult myeloid leukaemia risk (OR =2:14; 95 per cent Cr.I. 1.0–5.5).
24(12)
1849
1864
S. TOTI; A. BIGGERI; F. FORASTIERE
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2158/200493
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