The new fluorescent lipophilic moiety 11-[(7-amino-4-methyl-2-oxo-2H-1-benzopyran-3-acetyl)amino]undecanoic acid (AMCA-oAud-OH) was introduced by SPPS at the N-terminus of the immunodominant epitope GpMBP(74–85). FRET experiments using the new fluorescent lipopeptide demonstrate that the peptide interacts with much more affinity with the membrane compared to the lipid free analogue,
A new lipophilic fluorescent probe for interaction studies of bioactive lipopeptides with membrane models / PERONI E.; CAMINATI G.; P. BAGLIONI; NUTI F.; CHELLI M.; PAPINI A. M.. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - STAMPA. - 12:(2002), pp. 1731-1734.
A new lipophilic fluorescent probe for interaction studies of bioactive lipopeptides with membrane models
CAMINATI, GABRIELLA;BAGLIONI, PIERO;NUTI, FRANCESCA;PAPINI, ANNA MARIA
2002
Abstract
The new fluorescent lipophilic moiety 11-[(7-amino-4-methyl-2-oxo-2H-1-benzopyran-3-acetyl)amino]undecanoic acid (AMCA-oAud-OH) was introduced by SPPS at the N-terminus of the immunodominant epitope GpMBP(74–85). FRET experiments using the new fluorescent lipopeptide demonstrate that the peptide interacts with much more affinity with the membrane compared to the lipid free analogue,
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