Zn(II) coordination by the phenanthroline-containing macrocycle 2,6,10,14-tetraaza[15](2,9)cyclo(1,10)-phenanthrolinophane (L4) has been studied by means of potentiometric measurements in aqueous solution. Its coordination properties have been compared with those of other phenanthroline- or dipyridine-containing open-chain (L1, L2) or cyclic (L3) ligands. ATP binding to the Zn(II) complexes with L1-L4 has been examined by means of potentiometric and 1H and 31P NMR measurements in aqueous solution. In the ATP adducts with the [ZnL]2+ complexes, the nucleotide interacts with the metal via the terminal Pγ phosphate group; the equilibrium constants for the addition of ATP to the complexes depend on the number and arrangement of the nitrogen donors coordinated to the metal ion. Protonation of the [ZnL]2+ complexes gives [ZnHxL](x + 2)+ species, which contain two binding sites for the phosphate chain of ATP; while the Pγ phosphate group gives a coordination bond with the metal, the Pp one interacts via P-O- ⋯ H-N+ salt bridges with the ammonium functions of the complex. In consequence, protonated complexes are better ATP receptors than the simple [ZnL]2+ species and even than the protonated forms [HxL]x+ of the ligands, due to the synergetic action of the metal ion and of ammonium functions in ATP binding.
Protonated macrocyclic Zn(II) complexes as polyfunctional receptors for ATP / C. BAZZICALUPI; A. BENCINI; E. BERNI; A. BIANCHI; P. FORNASARI; C. GIORGI; C.MARINELLI; B.VALTANCOLI. - In: DALTON TRANSACTIONS. - ISSN 1477-9226. - STAMPA. - ...:(2003), pp. 2564-2572. [10.1039/b303264g]
Protonated macrocyclic Zn(II) complexes as polyfunctional receptors for ATP
BAZZICALUPI, CARLA;BENCINI, ANDREA
;BIANCHI, ANTONIO
;GIORGI, CLAUDIA;VALTANCOLI, BARBARA
2003
Abstract
Zn(II) coordination by the phenanthroline-containing macrocycle 2,6,10,14-tetraaza[15](2,9)cyclo(1,10)-phenanthrolinophane (L4) has been studied by means of potentiometric measurements in aqueous solution. Its coordination properties have been compared with those of other phenanthroline- or dipyridine-containing open-chain (L1, L2) or cyclic (L3) ligands. ATP binding to the Zn(II) complexes with L1-L4 has been examined by means of potentiometric and 1H and 31P NMR measurements in aqueous solution. In the ATP adducts with the [ZnL]2+ complexes, the nucleotide interacts with the metal via the terminal Pγ phosphate group; the equilibrium constants for the addition of ATP to the complexes depend on the number and arrangement of the nitrogen donors coordinated to the metal ion. Protonation of the [ZnL]2+ complexes gives [ZnHxL](x + 2)+ species, which contain two binding sites for the phosphate chain of ATP; while the Pγ phosphate group gives a coordination bond with the metal, the Pp one interacts via P-O- ⋯ H-N+ salt bridges with the ammonium functions of the complex. In consequence, protonated complexes are better ATP receptors than the simple [ZnL]2+ species and even than the protonated forms [HxL]x+ of the ligands, due to the synergetic action of the metal ion and of ammonium functions in ATP binding.File | Dimensione | Formato | |
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