(+)-Lentiginosine is a powerful and selective inhibitor of amyloglucosidases and has become a reference compound in the field among derivatives related to imino sugars. The present review focuses on the several total syntheses of this alkaloid, which rely on either a chiral pool or on enantioselective approaches that have appeared since its isolation in 1990. A summary of biological assays and molecular dynamic studies which allowed the assignment of the correct absolute configuration of natural (+)-lentiginosine is reported.

(+)-Lentiginosine, a potent and selective inhibitor of amyloglucosidase: synthetic efforts and disputes on its absolute configuration / F. Cardona; A. Goti; A. Brandi. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - STAMPA. - 2007:(2007), pp. 1551-1565. [10.1002/ejoc.200600633]

(+)-Lentiginosine, a potent and selective inhibitor of amyloglucosidase: synthetic efforts and disputes on its absolute configuration

CARDONA, FRANCESCA;GOTI, ANDREA;BRANDI, ALBERTO
2007

Abstract

(+)-Lentiginosine is a powerful and selective inhibitor of amyloglucosidases and has become a reference compound in the field among derivatives related to imino sugars. The present review focuses on the several total syntheses of this alkaloid, which rely on either a chiral pool or on enantioselective approaches that have appeared since its isolation in 1990. A summary of biological assays and molecular dynamic studies which allowed the assignment of the correct absolute configuration of natural (+)-lentiginosine is reported.
2007
2007
1551
1565
F. Cardona; A. Goti; A. Brandi
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/202266
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