Neandertals are documented in Europe and Western Asia from about 230,000 to 29,000 years ago. Analyses of mitochondrial DNA (mtDNA) from Neandertal samples [1,2] and other analyses [3,4,5] appear incompatible with the hypothesis that Neandertals are direct ancestors of modern Europeans [6,7]. However, there are broad geographic gaps in the sampling of Neandertal DNA diversity. Here, we describe the sequence of the first mitochondrial hypervariable region (HVR1) in a new specimen from Monti Lessini (MLS) in Northern Italy. This sequence contains several previously unidentified nucleotide substitutions and comparison to five other complete HVR1 sequences reveals a previously undetected amount of genetic variation among Neandertals.
A highly divergent mtDNA sequence in a Neandertal individual from Italy / D. CARAMELLI; LALUEZA-FOX C; CONDEMI S; LONGO L; MILANI L; MANFREDINI A; DE SAINT PIERRE M; ADONI F; LARI M; GIUNTI P; RICCI S; CASOLI A; CALAFELL F; MALLEGNI F; BERTRANPETIT J; STANYON R; BERTORELLE G; BARBUJANI G. - In: CURRENT BIOLOGY. - ISSN 0960-9822. - STAMPA. - 16:(2006), pp. 630-632. [10.1016/j.cub.2006.07.043]
A highly divergent mtDNA sequence in a Neandertal individual from Italy.
CARAMELLI, DAVID;LARI, MARTINA;STANYON, ROSCOE ROBERT;
2006
Abstract
Neandertals are documented in Europe and Western Asia from about 230,000 to 29,000 years ago. Analyses of mitochondrial DNA (mtDNA) from Neandertal samples [1,2] and other analyses [3,4,5] appear incompatible with the hypothesis that Neandertals are direct ancestors of modern Europeans [6,7]. However, there are broad geographic gaps in the sampling of Neandertal DNA diversity. Here, we describe the sequence of the first mitochondrial hypervariable region (HVR1) in a new specimen from Monti Lessini (MLS) in Northern Italy. This sequence contains several previously unidentified nucleotide substitutions and comparison to five other complete HVR1 sequences reveals a previously undetected amount of genetic variation among Neandertals.File | Dimensione | Formato | |
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