Clioquinol, a 8-hydroxyquinoline derivative, is producing very encouraging results in the treatment of Alzheimer’s disease (AD). Its biological effects are most likely ascribed to complexation of specific metal ions, such as copper(II) and zinc(II), critically associated with protein aggregation and degeneration processes in the brain. We report here, for the first time, a structural characterization of the zinc(II) and copper(II) complexes of clioquinol. A ligand to metal stoichiometry of 2:1 is found in both cases, though in the presence of quite different coordination polyhedra. The present findings are discussed in the frame of modern approaches to AD treatment.

Clioquinol, a drug for Alzheimer's disease specifically interfering with brain metal metabolism: structural characterization of its Zinc(II) and Copper(II) complexes / M. DI VAIRA; C. BAZZICALUPI; P. ORIOLI; L. MESSORI; B. BRUNI; P. ZATTA. - In: INORGANIC CHEMISTRY. - ISSN 0020-1669. - STAMPA. - 43:(2004), pp. 3795-3797. [10.1021/ic0494051]

Clioquinol, a drug for Alzheimer's disease specifically interfering with brain metal metabolism: structural characterization of its Zinc(II) and Copper(II) complexes

BAZZICALUPI, CARLA;MESSORI, LUIGI;BRUNI, BRUNO;
2004

Abstract

Clioquinol, a 8-hydroxyquinoline derivative, is producing very encouraging results in the treatment of Alzheimer’s disease (AD). Its biological effects are most likely ascribed to complexation of specific metal ions, such as copper(II) and zinc(II), critically associated with protein aggregation and degeneration processes in the brain. We report here, for the first time, a structural characterization of the zinc(II) and copper(II) complexes of clioquinol. A ligand to metal stoichiometry of 2:1 is found in both cases, though in the presence of quite different coordination polyhedra. The present findings are discussed in the frame of modern approaches to AD treatment.
43
3795
3797
M. DI VAIRA; C. BAZZICALUPI; P. ORIOLI; L. MESSORI; B. BRUNI; P. ZATTA
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2158/208248
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