In this paper, we investigate the formation of tumour cords (cylindrical arrangements of tumour cells around blood vessels) within a tumour tissue. The shrinkage and the expansion of the cord following a stepwise decrease or, respectively, increase of oxygen tension in the blood vessel are also described. The model represents the tumour cell population as a continuum and includes two novel aspects with respect to our previous works: cell death does not occur instantaneously, but is preceded by a reversible prenecrotic state; the recruitment of cells from quiescence into proliferation may require a recovery period. Model predictions are compared with experimental data reported by Hirst et al.

Dynamics of tumour cords following changes in oxygen availability: a model including a delayed exit from quiescence / BERTUZZI A.; A. FASANO; FILIDORO L.; GANDOLFI A.; SINISGALLI A. - In: MATHEMATICAL AND COMPUTER MODELLING. - ISSN 0895-7177. - STAMPA. - 41:(2005), pp. 1119-1135. [10.1016/j.mcm.2005.05.007]

Dynamics of tumour cords following changes in oxygen availability: a model including a delayed exit from quiescence

FASANO, ANTONIO;
2005

Abstract

In this paper, we investigate the formation of tumour cords (cylindrical arrangements of tumour cells around blood vessels) within a tumour tissue. The shrinkage and the expansion of the cord following a stepwise decrease or, respectively, increase of oxygen tension in the blood vessel are also described. The model represents the tumour cell population as a continuum and includes two novel aspects with respect to our previous works: cell death does not occur instantaneously, but is preceded by a reversible prenecrotic state; the recruitment of cells from quiescence into proliferation may require a recovery period. Model predictions are compared with experimental data reported by Hirst et al.
2005
41
1119
1135
BERTUZZI A.; A. FASANO; FILIDORO L.; GANDOLFI A.; SINISGALLI A
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/209728
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