Single cardiac myocytes provide a Model widely used to characterize the electrophysiological properties of drugs and to identify new therapeutic targets. This review focuses on isolation procedures to obtain single cardiac myocytes from several mammal species, including humans, and on patch-clamp technique as a useful method to investigate the molecular mechanism of druy actions. (C) 2000 Academic Press.
ISOLATED CARDIAC CELLS FOR ELECTROPHARMACOLOGICAL STUDIES / E. CERBAI; L. SARTIANI; P. DE PAOLI; A. MUGELLI. - In: PHARMACOLOGICAL RESEARCH. - ISSN 1043-6618. - STAMPA. - 42:(2000), pp. 1-8. [10.1006/phrs.1999.0654]
ISOLATED CARDIAC CELLS FOR ELECTROPHARMACOLOGICAL STUDIES.
CERBAI, ELISABETTA;SARTIANI, LAURA;MUGELLI, ALESSANDRO
2000
Abstract
Single cardiac myocytes provide a Model widely used to characterize the electrophysiological properties of drugs and to identify new therapeutic targets. This review focuses on isolation procedures to obtain single cardiac myocytes from several mammal species, including humans, and on patch-clamp technique as a useful method to investigate the molecular mechanism of druy actions. (C) 2000 Academic Press.
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