A practical synthesis of 2-aminomethyl- and 2-hydroxymethyl-3,4- dihydroxypyrrolidines via stereocontrolled addition of TMSCN and LiCH 2OMOM to chiral 3,4 dihydro-2H-pyrroline N-oxides is reported.
Straightforward Synthesis of Enantiopure 2-Aminomethyl and 2-Hydroxymethyl Pyrrolidines with Complete Stereocontrol / M. MARRADI; S. CICCHI; J. DELSO; L. ROSI; T. TEJERO; P. MERINO; A. GOTI. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - STAMPA. - 46:(2005), pp. 1287-1290. [10.1016/j.tetlet.2004.12.119]
Straightforward Synthesis of Enantiopure 2-Aminomethyl and 2-Hydroxymethyl Pyrrolidines with Complete Stereocontrol
M. MARRADI;CICCHI, STEFANO;ROSI, LUCA;GOTI, ANDREA
2005
Abstract
A practical synthesis of 2-aminomethyl- and 2-hydroxymethyl-3,4- dihydroxypyrrolidines via stereocontrolled addition of TMSCN and LiCH 2OMOM to chiral 3,4 dihydro-2H-pyrroline N-oxides is reported.
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