Animal experiments have shown an increase in prepro-endothelin-1 (prepro-ET-1) mRNA expression in the clipped kidney but none in the aortic and mesenteric arteries in 2-kidney, 1-clip Goldblatt hypertensive rats. The present study was aimed at investigating whether plasma and renal endothelin-1 (ET-1) systems are differently activated in patients with renovascular hypertension (RH). The plasma concentration and urinary excretion of ET-1 were measured in 5 patients with RH (before and after successful renal angioplasty), in 7 patients with essential hypertension (EH), and in 8 normotensive control subjects. Immediately before renal angioplasty, plasma samples for ET-1 and plasma renin activity (PRA) measurements were withdrawn from the aorta and both renal veins. Unlike the PRA, the plasma ET-1 concentration did not significantly differ between the involved and the uninvolved sides. The urinary ET-1 excretion level (Fig 1) was markedly increased in patients with RH (30 ± 4 ng/g urinary creatinine (UC) vs 2.5 ± 0.2 ng/g UC and 2.6 ± 0.5 ng/g UC in control subjects and patients with EH, respectively; P < .001), whereas the plasma ET-1 concentration was normal (0.8 ± 0.2 pg/mL vs 0.65 ± 0.3 pg/mL and 0.8 ± 0.2 pg/mL in control subjects and EH, respectively, not significant). Renal angioplasty was followed in all patients by normalization of blood pressure and PRA. One week after angioplasty, urinary ET-1 decreased to one fourth of baseline (8.04 ± 5.23 ng/g UC, P < .001 vs values before angioplasty and P < .04 vs control subjects) and normalized 1 month thereafter (3.13 ± 1.62 ng/g UC, not significant vs control subjects), whereas plasma ET-1 remained steady. The present findings clearly indicate that in patients with RH, urinary ET-1 excretion is increased, whereas plasma ET-1 concentration remains normal. Successful percutaneous transluminal renal angioplasty induced a notable reduction in ET-1 urinary excretion, whereas it did not affect ET-1 plasma concentration.

ET-1 urinary excretion but not ET-1 plasma concentration is increased in renovascular hypertension / Cecioni, I.; Modesti, P.A.; Poggesi, L.; Rocchi, F.; Rega, L.; NERI SERNERI G.G.. - In: JOURNAL OF LABORATORY AND CLINICAL MEDICINE. - ISSN 0022-2143. - STAMPA. - 134:(1999), pp. 386-386. [10.1016/S0022-2143(99)90153-1]

ET-1 urinary excretion but not ET-1 plasma concentration is increased in renovascular hypertension.

MODESTI, PIETRO AMEDEO;POGGESI, LOREDANA;NERI SERNERI, GIAN GASTONE
1999

Abstract

Animal experiments have shown an increase in prepro-endothelin-1 (prepro-ET-1) mRNA expression in the clipped kidney but none in the aortic and mesenteric arteries in 2-kidney, 1-clip Goldblatt hypertensive rats. The present study was aimed at investigating whether plasma and renal endothelin-1 (ET-1) systems are differently activated in patients with renovascular hypertension (RH). The plasma concentration and urinary excretion of ET-1 were measured in 5 patients with RH (before and after successful renal angioplasty), in 7 patients with essential hypertension (EH), and in 8 normotensive control subjects. Immediately before renal angioplasty, plasma samples for ET-1 and plasma renin activity (PRA) measurements were withdrawn from the aorta and both renal veins. Unlike the PRA, the plasma ET-1 concentration did not significantly differ between the involved and the uninvolved sides. The urinary ET-1 excretion level (Fig 1) was markedly increased in patients with RH (30 ± 4 ng/g urinary creatinine (UC) vs 2.5 ± 0.2 ng/g UC and 2.6 ± 0.5 ng/g UC in control subjects and patients with EH, respectively; P < .001), whereas the plasma ET-1 concentration was normal (0.8 ± 0.2 pg/mL vs 0.65 ± 0.3 pg/mL and 0.8 ± 0.2 pg/mL in control subjects and EH, respectively, not significant). Renal angioplasty was followed in all patients by normalization of blood pressure and PRA. One week after angioplasty, urinary ET-1 decreased to one fourth of baseline (8.04 ± 5.23 ng/g UC, P < .001 vs values before angioplasty and P < .04 vs control subjects) and normalized 1 month thereafter (3.13 ± 1.62 ng/g UC, not significant vs control subjects), whereas plasma ET-1 remained steady. The present findings clearly indicate that in patients with RH, urinary ET-1 excretion is increased, whereas plasma ET-1 concentration remains normal. Successful percutaneous transluminal renal angioplasty induced a notable reduction in ET-1 urinary excretion, whereas it did not affect ET-1 plasma concentration.
1999
134
386
386
Cecioni, I.; Modesti, P.A.; Poggesi, L.; Rocchi, F.; Rega, L.; NERI SERNERI G.G.
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/213805
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