A case of malignant melanoma arising in a young patient suffering from human immunodeficiency virus (HIV) infection is reported, along with a review of the literature. The neoplasm was characterized by aggressive clinical behaviour and, histopathologically, by a peculiar retiform pattern of growth with neoplastic cells interspersed among collagen bundles in the dermis without evident fibroplastic stromal reaction. In addition, a complete absence of host inflammatory cell infiltrate was noted. We hypothesize that this unusual histopathological pattern of growth, which has never been reported in this clinical setting, might be associated to HIV disease, immunosuppression and poor clinical outcome
Malignant Melanoma Associated with Human Immunodeficiency Virus (HIV) Infection: a case report and review of the literature / MASSI D.; BORGOGNONI L.; U. REALI; FRANCHI A.. - In: MELANOMA RESEARCH. - ISSN 0960-8931. - STAMPA. - 8:(1998), pp. 187-192.
Malignant Melanoma Associated with Human Immunodeficiency Virus (HIV) Infection: a case report and review of the literature
MASSI, DANIELA;REALI, UMBERTO MARIA;FRANCHI, ALESSANDRO
1998
Abstract
A case of malignant melanoma arising in a young patient suffering from human immunodeficiency virus (HIV) infection is reported, along with a review of the literature. The neoplasm was characterized by aggressive clinical behaviour and, histopathologically, by a peculiar retiform pattern of growth with neoplastic cells interspersed among collagen bundles in the dermis without evident fibroplastic stromal reaction. In addition, a complete absence of host inflammatory cell infiltrate was noted. We hypothesize that this unusual histopathological pattern of growth, which has never been reported in this clinical setting, might be associated to HIV disease, immunosuppression and poor clinical outcomeI documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.