Experimental autoimmune encephalomyelitis (EAE) in outbred marmoset monkeys (Callithrix jacchus) is a recently developed nonhuman primate model of multiple sclerosis. Here, Bert 't Hart and colleagues compare this model to EAE in rhesus monkeys, highlighting autoimmune mechanisms in CNS inflammation and demyelination, including the role of major histocompatibility complex restriction and preclinical evaluation of innovative immunotherapies.
A new primate model for multiple sclerosis in the common marmoset / 'T HART B.A.; VAN MEURS M.; BROK H.P.M.; MASSACESI L; BAUER J.; BOON L.; BONTROP R.E.; LAMAN J.D.;. - In: IMMUNOLOGY TODAY. - ISSN 0167-5699. - ELETTRONICO. - 21:(2000), pp. 290-297. [10.1016/S0167-5699(00)01627-3]
A new primate model for multiple sclerosis in the common marmoset.
MASSACESI, LUCA;
2000
Abstract
Experimental autoimmune encephalomyelitis (EAE) in outbred marmoset monkeys (Callithrix jacchus) is a recently developed nonhuman primate model of multiple sclerosis. Here, Bert 't Hart and colleagues compare this model to EAE in rhesus monkeys, highlighting autoimmune mechanisms in CNS inflammation and demyelination, including the role of major histocompatibility complex restriction and preclinical evaluation of innovative immunotherapies.
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