Massacesi L è parte del "Italian Group for MS genetics". Abstract: Multiple sclerosis is a chronic inflammatory disease of the central nervous system with a genetic component. Until now, the more consistent association with the disease is found with the major histocompatibility complex, especially HLA-DRB1*1501-DQB1*0602 haplotype. In this report, we demonstrate the interaction of Cytotoxic T Lymphocyte-associated antigen 4 (CTLA-4 [CD152]) gene with DRB1*15 haplotype in multiple sclerosis genetic susceptibility. Our data were obtained from two European independent family-based studies including 610 multiple sclerosis family trios.
Genetic interaction of CTLA-4 with HLA-DR15 in multiple sclerosis patients / ALIZADEH M; BABRON MC; BIREBENT B; MATSUDA F; QUELVENNEC E; LIBLAU R; COURNU-REBEIX I; MOMIGLIANO-RICHIARDI P; SEQUEIROS J; YAOUANQ J; GENIN E; VASILESCU A; BOUGERIE H; TROJANO M; MARTINS SILVA B; MACIEL P; CLERGET-DARPOUX F; CLANET M; EDAN G; FONTAINE B; THE ITALIAN GROUP FOR MS GENETICS; L. MASSACESI. - In: ANNALS OF NEUROLOGY. - ISSN 0364-5134. - ELETTRONICO. - 54:(2003), pp. 119-122. [10.1002/ana.10617]
Genetic interaction of CTLA-4 with HLA-DR15 in multiple sclerosis patients.
MASSACESI, LUCA
2003
Abstract
Massacesi L è parte del "Italian Group for MS genetics". Abstract: Multiple sclerosis is a chronic inflammatory disease of the central nervous system with a genetic component. Until now, the more consistent association with the disease is found with the major histocompatibility complex, especially HLA-DRB1*1501-DQB1*0602 haplotype. In this report, we demonstrate the interaction of Cytotoxic T Lymphocyte-associated antigen 4 (CTLA-4 [CD152]) gene with DRB1*15 haplotype in multiple sclerosis genetic susceptibility. Our data were obtained from two European independent family-based studies including 610 multiple sclerosis family trios.
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