Massacesi L è parte del "Italian Group for MS genetics". Abstract: Multiple sclerosis is a chronic inflammatory disease of the central nervous system with a genetic component. Until now, the more consistent association with the disease is found with the major histocompatibility complex, especially HLA-DRB1*1501-DQB1*0602 haplotype. In this report, we demonstrate the interaction of Cytotoxic T Lymphocyte-associated antigen 4 (CTLA-4 [CD152]) gene with DRB1*15 haplotype in multiple sclerosis genetic susceptibility. Our data were obtained from two European independent family-based studies including 610 multiple sclerosis family trios.
Genetic interaction of CTLA-4 with HLA-DR15 in multiple sclerosis patients / ALIZADEH M, BABRON MC, BIREBENT B, MATSUDA F, QUELVENNEC E, LIBLAU R, COURNU-REBEIX I, MOMIGLIANO-RICHIARDI P, SEQUEIROS J, YAOUANQ J, GENIN E, VASILESCU A, BOUGERIE H, TROJANO M, MARTINS SILVA B, MACIEL P, CLERGET-DARPOUX F, CLANET M, EDAN G, FONTAINE B, et al.. - In: ANNALS OF NEUROLOGY. - ISSN 0364-5134. - ELETTRONICO. - 54:(2003), pp. 119-122. [10.1002/ana.10617]
Genetic interaction of CTLA-4 with HLA-DR15 in multiple sclerosis patients.
MASSACESI, LUCA
2003
Abstract
Massacesi L è parte del "Italian Group for MS genetics". Abstract: Multiple sclerosis is a chronic inflammatory disease of the central nervous system with a genetic component. Until now, the more consistent association with the disease is found with the major histocompatibility complex, especially HLA-DRB1*1501-DQB1*0602 haplotype. In this report, we demonstrate the interaction of Cytotoxic T Lymphocyte-associated antigen 4 (CTLA-4 [CD152]) gene with DRB1*15 haplotype in multiple sclerosis genetic susceptibility. Our data were obtained from two European independent family-based studies including 610 multiple sclerosis family trios.
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