Drug adduct: The X-ray crystal structure of an adduct of cisplatin and bovine erythrocyte superoxide dismutase has been solved at 1.8-Å resolution. Selective platination of His19 occurs far away from the copper–zinc site. Remarkably, the protein-bound platinum center retains both chloro ligands
Structural Investigation of Cisplatin-Protein Interactions: Selective Platination of His 19 in Cuprozinc Superoxide Dismutase / V. CALDERONE; A. CASINI; S. MANGANI; L. MESSORI; P.ORIOLI. - In: ANGEWANDTE CHEMIE. INTERNATIONAL EDITION. - ISSN 1433-7851. - STAMPA. - 45:(2006), pp. 1267-1269. [10.1002/anie.200502599]
Structural Investigation of Cisplatin-Protein Interactions: Selective Platination of His 19 in Cuprozinc Superoxide Dismutase
V. CALDERONE;A. CASINI;L. MESSORI;P. ORIOLI
2006
Abstract
Drug adduct: The X-ray crystal structure of an adduct of cisplatin and bovine erythrocyte superoxide dismutase has been solved at 1.8-Å resolution. Selective platination of His19 occurs far away from the copper–zinc site. Remarkably, the protein-bound platinum center retains both chloro ligands
File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
messori calderone.pdf
Accesso chiuso
Tipologia:
Versione finale referata (Postprint, Accepted manuscript)
Licenza:
Tutti i diritti riservati
Dimensione
263.28 kB
Formato
Adobe PDF
|
263.28 kB | Adobe PDF | Richiedi una copia |
I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
