Our results suggests that reperfusion of ischemic myocardium, as occurs in course of heart transplantation, may represent a critical event to trigger apoptosis. The mechanisms by which oxidative stress induces apoptosis in the adult I-R myocardium seem to be independent of p53 gene expression. Studies are in progress in our laboratory to delineate the genetic component of the apoptotic process elicited by ischemia–reperfusion in transplanted heart.
Ischemia-reperfusion induced apoptosis and p53 expression in the course of rat heterotopic heart transplantation / L. FORMIGLI; L. IBBA-MANNESCHI; A.M. PERNA; C. NEDIANI; P. LIGUORI; A. TANI; S. ZECCHI-ORLANDINI. - In: MICROVASCULAR RESEARCH. - ISSN 0026-2862. - STAMPA. - 56:(1998), pp. 277-281.
Ischemia-reperfusion induced apoptosis and p53 expression in the course of rat heterotopic heart transplantation
FORMIGLI, LUCIA;IBBA, LIDIA;NEDIANI, CHIARA;TANI, ALESSIA;ZECCHI, SANDRA
1998
Abstract
Our results suggests that reperfusion of ischemic myocardium, as occurs in course of heart transplantation, may represent a critical event to trigger apoptosis. The mechanisms by which oxidative stress induces apoptosis in the adult I-R myocardium seem to be independent of p53 gene expression. Studies are in progress in our laboratory to delineate the genetic component of the apoptotic process elicited by ischemia–reperfusion in transplanted heart.
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