cardiovascular diseases are major health problems in astronauts and pilots. The basic problem in cardiovascular diseases is the loss of function by vascular endothelium. It has been demonstrated that changes in inertial conditions (i.e. hypo- and hypergravity) can affect both phenotypic and genotypic expression in endothelial cells. This report describes the effects observed in endothelial cells from coronary post-capillary venules after repeated exposures to hypergravity conditions, alternating with recovery periods. The results showed changes in gene expression, cell energy metabolism, morphology and cytoskeleton organization.
Hypergravity affects morphology and function in microvascular endothelial cells / MONICI M; MARZILIANO N; BASILE V; PEZZATINI S; G. ROMANO; CONTI A.; MORBIDELLI L. - In: MICROGRAVITY, SCIENCE AND TECHNOLOGY. - ISSN 0938-0108. - STAMPA. - 18:(2006), pp. 234-238. [10.1007/BF02870417]
Hypergravity affects morphology and function in microvascular endothelial cells
ROMANO, GIOVANNI;CONTI, ANTONIO;
2006
Abstract
cardiovascular diseases are major health problems in astronauts and pilots. The basic problem in cardiovascular diseases is the loss of function by vascular endothelium. It has been demonstrated that changes in inertial conditions (i.e. hypo- and hypergravity) can affect both phenotypic and genotypic expression in endothelial cells. This report describes the effects observed in endothelial cells from coronary post-capillary venules after repeated exposures to hypergravity conditions, alternating with recovery periods. The results showed changes in gene expression, cell energy metabolism, morphology and cytoskeleton organization.
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