this is the first time that primary cell cultures from human fetal olfactory neuroepithelium have been shown to express and release GnRH. Our results also demonstrate that these cultures, which are sensitive to sex steroids and odorants, can be useful models in the study of the complex array of regulatory factors that finely tune GnRH secretion in humans.
Sex steroids and odorants modulate gonadotropin-releasing hormone secretion in primary cultures of human olfactory cells / BARNI T.; MAGGI M.; FANTONI G.; GRANCHI S.; MANCINA R; GULISANO M.; MARRA F.; MACORSINI E.; LUCONI M.; C. ROTELLA, SERIO M., BALBONI G.C. AND VANNELLI G.B.. - In: THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM. - ISSN 0021-972X. - STAMPA. - 84:(1999), pp. 4266-4277. [10.1210/jcem.84.11.6150]
Sex steroids and odorants modulate gonadotropin-releasing hormone secretion in primary cultures of human olfactory cells.
MAGGI, MARIO;GULISANO, MASSIMO;MARRA, FABIO;LUCONI, MICHAELA;ROTELLA, CARLO MARIA;
1999
Abstract
this is the first time that primary cell cultures from human fetal olfactory neuroepithelium have been shown to express and release GnRH. Our results also demonstrate that these cultures, which are sensitive to sex steroids and odorants, can be useful models in the study of the complex array of regulatory factors that finely tune GnRH secretion in humans.
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