mesangial IGF and TGF-beta1 synthesis is upregulated by AGE-modified proteins through an AGE-receptor-mediated mechanism. The parallelism with increased ECM (extra cellular matrix) production raises the speculation that the enhanced synthesis of these growth factors resulting from advanced nonenzymatic glycation participates in the pathogenesis of hyperglycemia-induced mesangial expansion.
Upregolation of mesangial growth factor and extracellular matrix synthesis by advanced glycation end products via receptor-mediated mechanism / PUGLIESE G; PRICCI F; ROMEO G.; PUGLIESE F; MENE’ P; GIANNINI S; CRESCI B; GALLI G; C. ROTELLA; VLASSARA H.; DI MARIO U.. - In: DIABETES. - ISSN 0012-1797. - ELETTRONICO. - 46:(1997), pp. 1881-1887.
Upregolation of mesangial growth factor and extracellular matrix synthesis by advanced glycation end products via receptor-mediated mechanism.
ROTELLA, CARLO MARIA;
1997
Abstract
mesangial IGF and TGF-beta1 synthesis is upregulated by AGE-modified proteins through an AGE-receptor-mediated mechanism. The parallelism with increased ECM (extra cellular matrix) production raises the speculation that the enhanced synthesis of these growth factors resulting from advanced nonenzymatic glycation participates in the pathogenesis of hyperglycemia-induced mesangial expansion.
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