hese experiments demonstrated that high glucose levels induce enhanced mesangial IGF activity, together with enhanced TGF-beta 1 gene expression, increased matrix production, and reduced cell proliferation. It is possible that IGFs participate in mediating diabetes-induced changes in matrix turnover leading to mesangial expansion, by acting in a paracrine/autocrine fashion within the glomerulus.
Increased activity of the isulin-like growth factor system in mesangial cells cultured in high glucose: role in glucose-enhanced extracellular matrix accumulation / PUGLIESE; F PRICCI; N LOCURATOLO; ROMEO G.; G ROMANO; S GIANNINI; CRESCI B; G. GALLI; C. ROTELLA; U. DI MARIO. - In: DIABETOLOGIA. - ISSN 0012-186X. - ELETTRONICO. - 39 (7)::(1996), pp. 775-784.
Increased activity of the isulin-like growth factor system in mesangial cells cultured in high glucose: role in glucose-enhanced extracellular matrix accumulation.
ROTELLA, CARLO MARIA;
1996
Abstract
hese experiments demonstrated that high glucose levels induce enhanced mesangial IGF activity, together with enhanced TGF-beta 1 gene expression, increased matrix production, and reduced cell proliferation. It is possible that IGFs participate in mediating diabetes-induced changes in matrix turnover leading to mesangial expansion, by acting in a paracrine/autocrine fashion within the glomerulus.
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