Leptin concentrations are not significantly modified in obese Type 2 diabetic patients. GLP-1(7-36)amide baseline concentrations are reduced in Type 2 diabetes; moreover, diabetic subjects show an impaired response of GLP-1 to oral glucose in euglycaemic, isoinsulinaemic conditions. This impairment, which is not the result of differences in glycaemia or insulinaemia during assessment, could contribute to the pathogenesis of hyperglycaemia in Type 2 diabetes mellitus.
Glucagon-like Peptide (GLP)-1 and leptin concentrations in obese patients with Type 2 diabetes mellitus / MANNUCCI E; OGNIBENA A; CREMASCO F.; BARDINI G.; MENCUCCI A.; PIERAZZUUOLI F.; CIANI S.; FANELLI A.; MESSERI G.; C. ROTELLA. - In: DIABETIC MEDICINE. - ISSN 0742-3071. - ELETTRONICO. - 17:(2000), pp. 713-719.
Glucagon-like Peptide (GLP)-1 and leptin concentrations in obese patients with Type 2 diabetes mellitus.
MANNUCCI, EDOARDO;ROTELLA, CARLO MARIA
2000
Abstract
Leptin concentrations are not significantly modified in obese Type 2 diabetic patients. GLP-1(7-36)amide baseline concentrations are reduced in Type 2 diabetes; moreover, diabetic subjects show an impaired response of GLP-1 to oral glucose in euglycaemic, isoinsulinaemic conditions. This impairment, which is not the result of differences in glycaemia or insulinaemia during assessment, could contribute to the pathogenesis of hyperglycaemia in Type 2 diabetes mellitus.
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