L-ascorbic acid, or Vitamin C, is a strong and powerful water-soluble antioxidant, that efficiently protects important organic and biological molecules against oxidative degradation. It works even better in conjunction with other antioxidants, such as vitamin E (tocopherols) and carotenoids, by establishing a peculiar recycling system with a synergic effect, that will be discussed later on. However, due to its very poor solubility in non-aqueous media, ascorbic acid cannot be used to protect hydrophobic systems such as fats, biomembrane lipids, or other vitamins. It is therefore essential to synthesize lipophilic derivatives that are soluble in hydrophobic phases, produce supramolecular aggregates in water, and hold the same antioxidant properties. A relevant part of this review is devoted to the explanation of the mechanism involved in the peroxidation of membrane lipids, and to the possible applications of ascorbic acid derivatives as antioxidant for the prevention and therapy of several diseases.
Supramolecular Aggregates from Vitamin C Derivatives: Structure and Properties / P. LO NOSTRO. - In: INTERNET JOURNAL OF SCIENCE - BIOLOGICAL CHEMISTRY. - ELETTRONICO. - 4:(1997), pp. 0-0.
Supramolecular Aggregates from Vitamin C Derivatives: Structure and Properties
LO NOSTRO, PIERANDREA
1997
Abstract
L-ascorbic acid, or Vitamin C, is a strong and powerful water-soluble antioxidant, that efficiently protects important organic and biological molecules against oxidative degradation. It works even better in conjunction with other antioxidants, such as vitamin E (tocopherols) and carotenoids, by establishing a peculiar recycling system with a synergic effect, that will be discussed later on. However, due to its very poor solubility in non-aqueous media, ascorbic acid cannot be used to protect hydrophobic systems such as fats, biomembrane lipids, or other vitamins. It is therefore essential to synthesize lipophilic derivatives that are soluble in hydrophobic phases, produce supramolecular aggregates in water, and hold the same antioxidant properties. A relevant part of this review is devoted to the explanation of the mechanism involved in the peroxidation of membrane lipids, and to the possible applications of ascorbic acid derivatives as antioxidant for the prevention and therapy of several diseases.File | Dimensione | Formato | |
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