Pulsed current iontophoresis of hyaluronic acid in living rat skin

LETTER TO THE EDITOR. Summary. Hyaluronic acid (HA) is a natural glycosaminoglycan (GAG) used in treatment and prevention of different skin diseases and as a filler agent for improving wrinkles, scars, or increasing volumes. Because of chemical structure, HA has to be injected repeatedly for many months, in tens or hundreds of sites, by experienced operators… In this study we evaluated theefficacy of a powered pulsed current iontophoresis drug delivery system (Transderm1 Ionto System, Mattioli Engineering, McLean, VA, USA) approved for clinical use in humans by the US Food and Drug Administration (FDA, approval no. K042590, 10.14.2004), in delivering HA through living rat skin… we hypothesize that pulsed current iontophoresis might allow transdermal passage of HA in a manner similar to that observed with GAGs in PAGE… it should be considered that being the treatment fast and painless, and avoiding all the problems associated with syringes and needles, it could be proposed as a safe alternative to injection.