Acetalic substituents strategically located in a pyrrolic tripodal structure provide a new synthetic receptor endowed with unprecedented affinity for mannosides and the highest selectivity for β-mannose ever reported for synthetic H-bonding receptors. Binding properties have been determined by NMR, ITC, and ESI-MS techniques, while affinities have been univocally assessed by the BC500 parameter, a general descriptor of binding affinity.
A b-Mannoside-Selective Pyrrolic Tripodal Receptor / C. NATIVI; M. CACCIARINI; O. FRANCESCONI; G. MONETI; S. ROELENS. - In: ORGANIC LETTERS. - ISSN 1523-7060. - STAMPA. - 9:(2007), pp. 4685-4688. [10.1021/ol701959r]
A b-Mannoside-Selective Pyrrolic Tripodal Receptor
NATIVI, CRISTINA;CACCIARINI, MARTINA;FRANCESCONI, OSCAR;MONETI, GLORIANO;
2007
Abstract
Acetalic substituents strategically located in a pyrrolic tripodal structure provide a new synthetic receptor endowed with unprecedented affinity for mannosides and the highest selectivity for β-mannose ever reported for synthetic H-bonding receptors. Binding properties have been determined by NMR, ITC, and ESI-MS techniques, while affinities have been univocally assessed by the BC500 parameter, a general descriptor of binding affinity.
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