2-Aminoalkanesulfonic acids have been synthesized by a three-component alkene/SO3·DMF/acetonitrile reaction, followed by hydrolysis. Trifluoromethanesulfonic acid was added to the amino-sulfonation mixture to accelerate the reaction and prevent the competitive formation of by-products. The reported two-step procedure provided a concise and versatile approach to new analogues of the natural amino acid taurine.
Synthesis of Taurine Analogues, Part 2. Amino-Sulfonation of Alkenes by a Three Component Reaction / F. M. CORDERO; M. CACCIARINI; F. MACHETTI; F. DE SARLO. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - STAMPA. - 2002:(2002), pp. 1407-1411.
Synthesis of Taurine Analogues, Part 2. Amino-Sulfonation of Alkenes by a Three Component Reaction
CORDERO, FRANCA MARIA;CACCIARINI, MARTINA;MACHETTI, FABRIZIO;DE SARLO, FRANCESCO
2002
Abstract
2-Aminoalkanesulfonic acids have been synthesized by a three-component alkene/SO3·DMF/acetonitrile reaction, followed by hydrolysis. Trifluoromethanesulfonic acid was added to the amino-sulfonation mixture to accelerate the reaction and prevent the competitive formation of by-products. The reported two-step procedure provided a concise and versatile approach to new analogues of the natural amino acid taurine.
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