During evolution microorganisms have developed several immune modulating strategies. The Helicobacter pylori neutrophil-activating protein (HP-NAP) is a virulence factor that attracts and activates neutrophils, and promotes their endothelial adhesion and the production of oxygen radicals and chemokines, including CXCL8, CCL3 and CCL4. HP-NAP, a TLR2 agonist, is an immune modulator able to induce the expression of interleukin-12 (IL-12) and IL-23 by human neutrophils and monocytes. In fact, HP-NAP has the potential to shift antigen-specific T-cell responses from a predominant Th2 to a polarized Th1 cytotoxic phenotype, characterized by high levels of interferon-g and tumor necrosis factor-a production. Thus, HP-NAP is a key factor driving Th1 inflammation in H. pylori infection and may be a new tool for future therapeutic strategies aimed at redirecting Th2 into Th1 responses, for example in atopy, vaccinology and cancer immunotherapy.
The neutrophil-activating protein (HP-NAP) of Helicobacter pylori as immune modulating agent / D'Elios, MARIO MILCO; Amedei, Amedeo; Cappon, A; DEL PRETE, Gianfranco; de Bernard, M.. - In: FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY. - ISSN 0928-8244. - STAMPA. - 50:(2007), pp. 157-164.
The neutrophil-activating protein (HP-NAP) of Helicobacter pylori as immune modulating agent.
D'ELIOS, MARIO MILCO;AMEDEI, AMEDEO;DEL PRETE, GIANFRANCO;
2007
Abstract
During evolution microorganisms have developed several immune modulating strategies. The Helicobacter pylori neutrophil-activating protein (HP-NAP) is a virulence factor that attracts and activates neutrophils, and promotes their endothelial adhesion and the production of oxygen radicals and chemokines, including CXCL8, CCL3 and CCL4. HP-NAP, a TLR2 agonist, is an immune modulator able to induce the expression of interleukin-12 (IL-12) and IL-23 by human neutrophils and monocytes. In fact, HP-NAP has the potential to shift antigen-specific T-cell responses from a predominant Th2 to a polarized Th1 cytotoxic phenotype, characterized by high levels of interferon-g and tumor necrosis factor-a production. Thus, HP-NAP is a key factor driving Th1 inflammation in H. pylori infection and may be a new tool for future therapeutic strategies aimed at redirecting Th2 into Th1 responses, for example in atopy, vaccinology and cancer immunotherapy.File | Dimensione | Formato | |
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